Professor Chen Lin
Posted on: 2024-05-16
Specialties：Sleep Medicine、Cardiovascular Physiology、Portable Medical Devices、Digital Health、Applications of Real-time Monitoring
Contact Information：03-4227151 (27756)
E-mail：dreamtheater.lin@gmail.com
Education
2008/08~2012/07
National Central University, Taiwan
Ph.D. in Institute of Systems Biology and Bioinformatics
Current Position
2025/08~present
Professor, Department of Biomedical Sciences and Engineering, National Central University
Previous appointments and professional experiences
2020/08~2025/07
Associate Professor, Department of Biomedical Sciences and Engineering, National Central University
2015/08~2020/07
Assistant Professor, Department of Biomedical Sciences and Engineering, National Central University
2014/02~2015/07
Assistant Research Fellow
Center for Adaptive Data Analysis, National Central University
2013/09~2017/04
Taiwanese Team of Qualcomm Tricorder XPRIZE Competition (Co-PI in Vital Sign Group)
2012/09~2013/09
Post-Doctoral Fellow
Department of Behavioral Science and Psychiatry, Stanford University
Publications
1.Han-Luen Huang, Chia-Hsiu Chang, Men‑Tzung Lo, Chen Lin* (2024) Diagnostic Potential of Combined Photoplethysmography and Ankle-Brachial Index in Peripheral Arterial Disease: A Duplex Ultrasonography-Based Comparative Study. Journal of the American Heart Association, 13(19): e034625 * correspondence
2.Hai-Hua Chuang, Yu-Hsuan Lin, Li-Ang Lee, Hsiang-Chih Chang, Guan-Jie She, Chen Lin* (2024) The optimal measurement period of actigraphy for circadian rhythm in relation to adiposity: A retrospective case-control study. Sleep Medicine 122:1-7 * correspondence
3.Zeus Harnod*, Chen Lin*, Hui-Wen Yang, Zih-Wen Wang, Han-Luen Huang, Tse-Yu Lin, Chun-Yao Huang, Lian-Yu Lin, Hsu-Wen V. Young, Men-Tzung Lo (2024) A transferable in-silico augmented ischemic model for virtual myocardial perfusion imaging and myocardial infarction detection. Medical Image Analysis 103087 *co-first author
4.Shu-Yu Tang, Hsi-Pin Ma, Chen Lin*, Men-Tzung Lo, Lian-Yu Lin, Tsung-Yan Chen, Cho-Kai Wu, Jiun-Yang Chiang, Jen-Kuang Lee, Chi-Sheng Hung, Li-Yu Daisy Liu, Yu-Wei Chiu, Cheng-Hsuan Tsai, Yen-Tin Lin, Chung-Kang Peng & Yen-Hung Lin (2023) Heart rhythm complexity analysis in patients with inferior ST-elevation myocardial infarction Scientific Reports, 20861. *co-correspondence
5.Jien-Jiun Chen, Chen Lin*, Men-Tzung Lo, Lian-Yu Lin, Hsiang-Chih Chang, Geng-Chi Liu (2024) Autonomic modulation by SGLT2i or DPP4i in patients with diabetes favors cardiovascular outcomes as revealed by skin sympathetic nerve activity. Frontiers in Pharmacology 15:1424544 *co-correspondence
6.Chen Lin, I-Ming Chen, Hai-Hua Chuang, Zih-Wen Wang, Hsiao-Han Lin Yu-Hsuan Lin (2023) Examining Human-Smartphone Interaction as a Proxy for Circadian Rhythm in Patients with Insomnia: A Cross-Sectional Study. Journal of Medical Internet Research 25:e48044
7.Jien-Jiun Chen, Chen Lin*, Yuan-Cheng Chuang, Shu-Fang Lee, Tse-Yu Lin, Chieh-Cheh Yu, Chia-Ti Tsai, Min-Tsun Liao, Tin-Tse Lin, Lian-Yu Lin, Men-Tzung Lo (2022) Alterations of sympathetic dynamics after atrial fibrillation ablation by analysis sympathetic nerve activity provide prognostic value for recurrence and mechanistic insights into ablation. Frontiers in Cardiovascular Medicine, 9:1024156 *co-correspondence
8.Hui-Wen Yang, Cheng-Yi Hsiao, Yu-Qi Peng, Tse-Yu Lin, Lung-Wen Tsai, Chen Lin*, Men-Tzung Lo, Chun-Ming Shih (2022) Identification of Patients with Potential Atrial Fibrillation during Sinus Rhythm Using Isolated P Wave Characteristics from 12-Lead ECGs. Journal of Personalized Medicine, 12(10):1608 *co-correspondence
9.Chen Lin, Wei-Chih Chin, Yu-Shu Huang, Kuo-Chung Chu, Teresa Paiva, Chia-Chi Chen, Christian Guilleminault (2021). Different circadian rest-active rhythms in Kleine-Levin syndrome: a prospective and case-control study. Sleep, 44(9): zsab096.
10.Hsin-Yi Wang, Men-Tzung Lo, Kun-Hui Chen, Susan Mandell, Wen-Kuei Chang, Chen Lin*, Chien-Kun Ting (2021) Strong Early Phase Parasympathetic Inhibition Followed by Sympathetic Withdrawal During Propofol Induction: Temporal Response Assessed by Wavelet-Based Spectral Analysis and Photoplethysmography. Frontiers in Physiology, 705153. *co-correspondence
11.Yuan-Hung Pong, Yi-Kai Chang, Ching-En Hsu, Po-Cheng Chen, Yu-Chuan Lu, Vincent F. S. Tsai, Hong-Chiang Chang, Men-Tzung Lo, Chen Lin* (2021). Probing penile hemodynamics by using photoplethysmography as objective indicators for male erection quality and sexual function. Scientific Reports, 12019. *correspondence
12.Hung-Hsun Chen, Chen Lin, Hsiang-Chih Chang, Jen-Ho Chang, Hai-Hua Chuang, Yu-Hsuan Lin (2024) Developing Methods for Assessing Mental Activity Using Human-Smartphone Interactions: Comparative Analysis of Activity Levels and Phase Patterns in General Mental Activities, Working Mental Activities, and Physical Activities. Journal of Medical Internet Research, 26:e56144
13.Huey-Wen Liang, Chueh-Hung Wu, Chen Lin, Hsiang-Chih Chang, Yu-Hsuan Lin, Shao-Yu Chen,Wei-Chen Hsu (2024) Rest-Activity Rhythm Differences in Acute Rehabilitation Between Poststroke Patients and Non–Brain Disease Controls: Comparative Study. Journal of Medical Internet Research, 26:e49530
14.Hai-Hua Chuang, Chen Lin, Li-Ang Lee, Hsiang-Chih Chang, Guan-Jie She, Yu-Hsuan Lin (2024) Comparing Human-Smartphone Interactions and Actigraphy Measurements for Circadian Rhythm Stability and Adiposity: Algorithm Development and Validation Study. Journal of Medical Internet Research, 26:e50149
15.Wei-Chih Chin, Yu-Shu Huang, Ngo Yan Trevor Lam, Ka Yu Mak, I Tang, Chih-Huan Wang, Chen Lin (2024) Effects of modafinil on nocturnal sleep patterns in patients with narcolepsy: A cohort study. Sleep Medicine, 119:95-102
16.Tzu-Fu Yeh, Chen Lin, Huang-Chih Sung (2023) A review of technological developments in lipid nanoparticle application for mRNA vaccination. Human Vaccines and Immunotherapeutics, 19(2):2256040
17.Chin-Yu Lin, Chia-Hsin Chiang, Abigail Louise D Te, Yenn-Jiang Lin, Men-Tzung Lo, Chen Lin, Shih-Lin Chang, Li-Wei Lo, Yu-Feng Hu, Fa-Po Chung, Ta-Chuan Tuan, Tze-Fan Chao, Jo-Nan Liao, Shih-Ann Chen (2023) Characterization and identification of atrial fibrillation drivers in patients with nonparoxysmal atrial fibrillation using simultaneous amplitude frequency electrogram transform. Journal of Cardiovascular Electrophysiology, 3(34),536-545.
18.Chin-Yu Lin, Yenn-Jiang Lin, Satoshi Higa, Wen-Chin Tsai, Men-Tzung Lo, Chia-Hsin Chiang, Shih-Lin Chang, Li-Wei Lo, Yu-Feng Hu, Tze-Fan Chao, Fa-Po Chung, Jo-Nan Liao, Ting-Yung Chang, Chen Lin, Ta-Chuan Tuan, Ling Kuo, Cheng-I Wu, Chih-Min Liu, Shin-Huei Liu, Ming-Jen Kuo, Ying-Chieh Liao, Chieh-Mao Chuang, Yun-Yu Chen, Yu-Cheng Hsieh, Shih-Ann Chen (2023) Catheter ablation with morphologic repetitiveness mapping for persistent atrial fibrillation. JAMA network open, 6(11):e2344535
19.Yu-Shu Huang, I Tang, Wei-Chih Chin, Ling-Sheng Jang, Chin-Pang Lee, Chen Lin, Chun-Pai Yang, Shu-Ling Cho (2022) The Subjective and Objective Improvement of Non-Invasive Treatment of Schumann Resonance in Insomnia—A Randomized and Double-Blinded Study. Nature and Science of Sleep, (14):1113-1124
20.Hsin Yi Wang, Jing Yang Liou, Chen Lin, Chien Kun Ting, Wen Kuei Chang, Men Tzung Lo, Chien Chang Chen (2022) Thermodynamic Interpretation of a Machine-Learning-Based Response Surface Model and Its Application to Pharmacodynamic Synergy between Propofol and Opioids. Mathematics, 10(10), 1651
21.Hsin-Yi Wang, Chen Lin, Chien-Chang Chen, Wei-Nung Teng, Kun-Hui Chen, Men-Tzung Lo, Chien-Kun Ting (2022) Improvement in vocal-cord visualization with Trachway video intubating stylet using direct oxygen flow and effective analysis of the fraction of inspired oxygen: a bench study. Journal of Clinical Monitoring and Computing, 36:1723–1730
22.Li-Ting Ho, Bess Ma Fabinal Serafico, Ching-En Hsu, Zhao-Wei Chen, Tse-Yu Lin, Chen Lin, Lian-Yu Lin, Men-Tzung Lo, Kuo-Liong Chien (2022) Preserved Electroencephalogram Power and Global Synchronization Predict Better Neurological Outcome in Sudden Cardiac Arrest Survivors. Frontiers in Physiology, 13:866844
23.Yi-Chia Wei, Chih-Chin Heather Hsu, Wen-Yi Huang, Yao-Liang Chen, Chemin Lin, Chih-Ken Chen, Chen Lin, Yu-Chiau Shyu, Ching-Po Lin (2021) White Matter Integrity Underlies the Physical-Cognitive Correlations in Subjective Cognitive Decline. Frontiers in Aging Neuroscience, 13:700764
24.Hui-Wen Yang, Marta Garaulet, Peng Li, Cristina Bandin, Chen Lin, Men-Tzung Lo and Kun Hu (2021) Daily rhythm of fractal cardiac dynamics links to weight loss resistance: interaction with clock 3111t/c genetic variant. Nutrients, 13(7):2463
25.Chin-Yu Lin, Yenn-Jiang Lin, Men-Tzung Lo, Chia-Hsin Chiang, Yun-Yu Chen, Ling Kuo, Shih-Lin Chang, Li-Wei Lo, Yu-Feng H, Tze-Fan Chao, Fa-Po Chung, Jo-Nan Liao, Ting-Yung Chang, Chen Lin, Ta-Chuan Tuan, Cheng-I Wu, Chih-Min Liu, Shin-Huei Liu, Wen-Han Cheng, Isaiah C Lugtu, Ankit Jain, An Nu-Khanh Ton, Dony Yugo Hermanto, Shih-Ann Chen (2021) Efficacy of Patient-Specific Strategy: Catheter Ablation Strategy of Persistent Atrial Fibrillation Based on Morphological Repetitiveness by Periodicity and Similarity. Circulation: Arrhythmia and Electrophysiology, 5(14): e009719
26.Shu-Yu Tang, Hsi-Pin Ma, Chi-Sheng Hung, Ping-Hung Kuo, Chen Lin, Men-Tzung Lo, Hsao-Hsun Hsu, Yu-Wei Chiu, Cho-Kai Wu, Cheng-Hsuan Tsai, Yen-Tin Lin, Chung-Kang Peng, Yen-Hung Lin (2021) The value of heart rhythm complexity in identifying high-risk pulmonary hypertension patients. Entropy, 6(23):753
27.Yu-Cheng Hsieh, Yenn-Jiang Lin, Men-Tzung Lo, Yun-Yu Chen, Chin-Yu Lin, Chen Lin, Fa-Po Chung, Li-Wei Lo, Shih-Lin Chang, Tze-Fan Chao, Yu-Feng Hu, Ta-Chuan Tuan, Jo-Nan Liao, Cheng-I Wu, Chih-Min Liu, Jennifer-Jeanne B Vicera, Chun-Chao Chen, Chye-Gen Chin, Isaiah C Lugtu, Ankit Jain, An Nu-Khanh Ton, Dony Yugo Hermanto, Shih-Ann Chen (2021) Efficacy of Patient-Specific Strategy: Catheter Ablation Strategy of Persistent Atrial Fibrillation Based on Morphological Repetitiveness by Periodicity and Similarity. Circulation Arrhythmia Electrophysiology, 14(5):e009719
28.Jien-Jiun Chen, Chen Lin, Wen-Pin Hsiao, Tai-Min Chu, Hui-Wen Yang, Men-Tzung Lo, Lian-Yu Lin, Shien-Fong Lin (2021) Complex dynamics of skin sympathetic nerve activities as a prognostic predictor for critically ill patients. Journal of the Formosan Medical Association, 120(1): 660-667
29.Cheng-Hsuan Tsai, Hsi-Pin Ma, Yen-Tin Lin, Chi-Sheng Hung, Shan-Hsuan Huang, Bei-Lin Chuang, Chen Lin, Men-Tzung Lo, Chung-Kang Peng, Yen-Hung Lin (2020) Usefulness of heart rhythm complexity in heart failure detection and diagnosis. Scientific Reports,1(10):14916
30.Pham V-T, Lin C*, Tran T-T, Su M-Y M., Lin Y-K, Nien C-T, Tseng W-Y I., Lin J-L, Lo M-T, Lin L-Y, Predicting ventricular tachyarrhythmia in patients with systolic heart failure based on texture features of the gray zone from contrast-enhanced magnetic resonance imaging. Journal of Cardiology, 2020, S0914-5087(20)30222-7 (*corresponding author)
Lin C, Lin P-F, Wang C-H, Juan C-H, Tran T-T, Nien C-T, Lin YJ, Wang C.Y., Yeh CH, and Lo MT, Probing age-related changes in cardio-respiratory dynamics by multimodal coupling assessment. Chaos, 2020, 30:033118
31.Lin Y-K, Kao C-C, Tseng C-H, Hsu C-E, Lin Y-J, Chen Y-C, Lin C*, and C-Y Huang, Noninvasive Hemodynamic Profiles during Hemodialysis in Patients with and without Heart Failure. Cardiorenal Medicine, 2020,10(4):243-256 (*corresponding author)
32.Lin C, Wong B-Y, Lo M-T, Chiu Y-C, and Lin Y-H, Development of an addiction index and delineation 15-year trends of illicit drugs from a nationwide drug enhancement database. Journal of Psychiatric Research, 2020, 120(1):131-136
33.Kao C-C, Tseng C-H, Lo M-T, Lin Y-K, Hsu C-Y, Wu Y-L, Chen H-H, Lin F-Y, C Lin*, and C-Y Huang Alteration autonomic control of cardiac function during hemodialysis predict cardiovascular outcomes in end stage renal disease patients Scientific Reports, 2019, 9:18783 (*corresponding author)
34.Tseng C-H, Lin C*, Chang H-C, Liu C-C, Serafico BMF, Wu L-C, Lin C-T, Hsu T, Huang C-Y, and M-T Lo Cloud-Based Artificial Intelligence System for Large-Scale Arrhythmia Screening Computer, 2019, 52(11):40-51 (*corresponding author)
35.Lin C*, Yeh C-H, Wang C-Y, Shi W, Serafico BMF, Wang C-H, Juan C-H, Young H-W Vincent, Lin Y-J, Yeh H-M, and Lo M-T, Robust Fetal Heart Beat Detection via R-peak Intervals Distribution. IEEE Transactions on Biomedical Engineering, 2019, 66(12):3310-3319 (* corresponding author)
36.Tsai C-H, Ma H-P, Lin Y-T, Hung C-S, Hsieh M-C, Chang T-Y, Kuo P-H, Lin C*, Lo M-T, Hsu H-H, Peng C-K, and Lin Y-H, Heart Rhythm Complexity Impairment in Patients with Pulmonary Hypertension, Scientific Reports, 2019, 9:10710 (*corresponding author)
37.Lin C, Lo M-T, and Guilleminault C, Exploring the abnormal modulation of the autonomic systems during nasal flow limitation in upper airway resistance syndrome by Hilbert–Huang transform. Frontiers in Medicine, 2017, 4(161)
38.Lin C, Chang Y-C, Cheng Y-C, Lai P-J, Yeh C-H, Hsieh W-H, Hu K, Wu J-T, Lee H-H, M-T Lo, and Y-L Ho, Probing the fractal pattern of heartbeats in Drosophila pupae by visible optical recording system Scientific Reports, 2016, 6: 31950
39.Tsai C-H, Huang J-W, Lin C., Ma H-P, Lo M-T, Liiu L-YD, Lin L-Y, Lin C-T, Hung C-S, Peng C-K, and Lin Y-H Heart Rhythm Complexity Predicts Long‐Term Cardiovascular Outcomes in Peritoneal Dialysis Patients: A Prospective Cohort Study. Journal of the American Heart Association, 2020, 9(2):e013036
40.Tran T-T, Pham V-T, Lin C, Yang HW, Wang YH, Shyu KK, Tseng WYI, Su MY, Lin LY, Lo M-T, “Empirical Mode Decomposition and Monogenic Signal-Based Approach for Quantification of Myocardial Infarction From MR Images” IEEE Journal of Biomedical and Health Informatics 2018,23(2):731-743
41.Yeh C-H, Juan C-H, Yeh H-M, Wang C.Y. Young H-WV, Lin J-L, Lin C, Lin L-Y, and Lo M-T The critical role of respiratory sinus arrhythmia on temporal cardiac dynamics. Journal of Applied Physiology, 2019, 127(6):1733-1741
42.Tran TT, Fang TY, Pham VT, Lin C, Wang PC, and Lo M-T, “Development of an Automatic Diagnostic Algorithm for Pediatric Otitis Media”, Otology & Neurotology, 2018 Sep;39(8):1060-1065.
43.Yang HW, Jeng SK, Young HWV, Lin C, Wang YH, Hu K, and Lo M-T, “A Minimum Arclength Method for Removing Spikes in Empirical Mode Decomposition”, IEEE ACCESS, 2019, 7:13284
44.Gao L, Li P, Hu C, To T, Patxot M, Falvey B, Wong PM, Scheer FAJL, Lin C, Lo MT,and Hu K “Nocturnal Heart Rate Variability Moderates the Association Between Sleep-Wake Regularity and Mood in Young Adults.” Sleep, 2019, 42(5)
45.Y.-H. Lin, M.-T. Lo, X.-M. Wu, C.-S. Hung, Y.-L. Ho, K.-D. Wu, C. Lin*, V.-C. Wu, M. Stowasser, C.-K. Peng and the TAIPAI Study Group “Adrenalectomy reverses the impaired heart rhythm complexity in patients with primary aldosteronism” Scientific Reports, 2015 5:11249 (*corresponding author)
46.M.-T Lo, Y.-C. Chang, C. Lin, Vincent H.-W. Young, Y.-H. Lin, Y.-L. Ho, C.-K. Peng, K. Hu “Outlier-resilient complexity analysis of heartbeat dynamics” Scientific Reports, 2015, 5:8836
47.P.-F. Lin, J. Tsao, M.-T. Lo, C. Lin, Y.-C. Chang “Symbolic Entropy of the Amplitude rather than the Instantaneous Frequency of EEG Varies in Dementia”, Entropy, 2015 Jan; 17(2): 560-579
Ministry of Science and Technology
2022-2025 Developing a portable, multi-modal device for cardiac function monitoring and a cloud-based system for the precision care of high-risk patients with cardiovascular disease.
2021-2022 Building Circadian Rhythm Prediction Model across Multiple Diseases from Long-term Continuous Physiological Signals-A Bench-to-Bedside Study
2019-2021 A Multi-Signal Based Automated Monitoring System for Pediatric Sleep Disorders
2017 Industry-Academy cooperation project of Hsinchu Science Park Bureau-“An integrated platform for early screening of sleep breathing disorders.”
2014-2017 Realization of a wearable device for biomarker detection and cloud computation based feedback (Subproject 3 : Exploiting biomarkers of physiological signals recorded from wearable devices by using adaptive data analysis)
Social Responsibility and Community Service
2022 – Partnered with the Rotary Club of Taipei Grand Park to organize atrial fibrillation screening for the elderly population in Taoyuan City.
2017–2021 – Collaborated with the Department of Public Health, Taoyuan City, to conduct atrial fibrillation screening during community cancer screening programs.
Joint Research Grants
2017 Joint Project of National Central University and Landseed Hospital-Exploring the associations among in-patient longitudinal changes of vital signs, laboratory data of acute exacerbations of chronic obstructive pulmonary disease and their prognosis by machine learning.”
Patent
Contact Information：03-4227151 (27756)
E-mail：dreamtheater.lin@gmail.com
Education
2008/08~2012/07
National Central University, Taiwan
Ph.D. in Institute of Systems Biology and Bioinformatics
Current Position
2025/08~present
Professor, Department of Biomedical Sciences and Engineering, National Central University
Previous appointments and professional experiences
2020/08~2025/07
Associate Professor, Department of Biomedical Sciences and Engineering, National Central University
2015/08~2020/07
Assistant Professor, Department of Biomedical Sciences and Engineering, National Central University
2014/02~2015/07
Assistant Research Fellow
Center for Adaptive Data Analysis, National Central University
2013/09~2017/04
Taiwanese Team of Qualcomm Tricorder XPRIZE Competition (Co-PI in Vital Sign Group)
2012/09~2013/09
Post-Doctoral Fellow
Department of Behavioral Science and Psychiatry, Stanford University
Publications
1.Han-Luen Huang, Chia-Hsiu Chang, Men‑Tzung Lo, Chen Lin* (2024) Diagnostic Potential of Combined Photoplethysmography and Ankle-Brachial Index in Peripheral Arterial Disease: A Duplex Ultrasonography-Based Comparative Study. Journal of the American Heart Association, 13(19): e034625 * correspondence
2.Hai-Hua Chuang, Yu-Hsuan Lin, Li-Ang Lee, Hsiang-Chih Chang, Guan-Jie She, Chen Lin* (2024) The optimal measurement period of actigraphy for circadian rhythm in relation to adiposity: A retrospective case-control study. Sleep Medicine 122:1-7 * correspondence
3.Zeus Harnod*, Chen Lin*, Hui-Wen Yang, Zih-Wen Wang, Han-Luen Huang, Tse-Yu Lin, Chun-Yao Huang, Lian-Yu Lin, Hsu-Wen V. Young, Men-Tzung Lo (2024) A transferable in-silico augmented ischemic model for virtual myocardial perfusion imaging and myocardial infarction detection. Medical Image Analysis 103087 *co-first author
4.Shu-Yu Tang, Hsi-Pin Ma, Chen Lin*, Men-Tzung Lo, Lian-Yu Lin, Tsung-Yan Chen, Cho-Kai Wu, Jiun-Yang Chiang, Jen-Kuang Lee, Chi-Sheng Hung, Li-Yu Daisy Liu, Yu-Wei Chiu, Cheng-Hsuan Tsai, Yen-Tin Lin, Chung-Kang Peng & Yen-Hung Lin (2023) Heart rhythm complexity analysis in patients with inferior ST-elevation myocardial infarction Scientific Reports, 20861. *co-correspondence
5.Jien-Jiun Chen, Chen Lin*, Men-Tzung Lo, Lian-Yu Lin, Hsiang-Chih Chang, Geng-Chi Liu (2024) Autonomic modulation by SGLT2i or DPP4i in patients with diabetes favors cardiovascular outcomes as revealed by skin sympathetic nerve activity. Frontiers in Pharmacology 15:1424544 *co-correspondence
6.Chen Lin, I-Ming Chen, Hai-Hua Chuang, Zih-Wen Wang, Hsiao-Han Lin Yu-Hsuan Lin (2023) Examining Human-Smartphone Interaction as a Proxy for Circadian Rhythm in Patients with Insomnia: A Cross-Sectional Study. Journal of Medical Internet Research 25:e48044
7.Jien-Jiun Chen, Chen Lin*, Yuan-Cheng Chuang, Shu-Fang Lee, Tse-Yu Lin, Chieh-Cheh Yu, Chia-Ti Tsai, Min-Tsun Liao, Tin-Tse Lin, Lian-Yu Lin, Men-Tzung Lo (2022) Alterations of sympathetic dynamics after atrial fibrillation ablation by analysis sympathetic nerve activity provide prognostic value for recurrence and mechanistic insights into ablation. Frontiers in Cardiovascular Medicine, 9:1024156 *co-correspondence
8.Hui-Wen Yang, Cheng-Yi Hsiao, Yu-Qi Peng, Tse-Yu Lin, Lung-Wen Tsai, Chen Lin*, Men-Tzung Lo, Chun-Ming Shih (2022) Identification of Patients with Potential Atrial Fibrillation during Sinus Rhythm Using Isolated P Wave Characteristics from 12-Lead ECGs. Journal of Personalized Medicine, 12(10):1608 *co-correspondence
9.Chen Lin, Wei-Chih Chin, Yu-Shu Huang, Kuo-Chung Chu, Teresa Paiva, Chia-Chi Chen, Christian Guilleminault (2021). Different circadian rest-active rhythms in Kleine-Levin syndrome: a prospective and case-control study. Sleep, 44(9): zsab096.
10.Hsin-Yi Wang, Men-Tzung Lo, Kun-Hui Chen, Susan Mandell, Wen-Kuei Chang, Chen Lin*, Chien-Kun Ting (2021) Strong Early Phase Parasympathetic Inhibition Followed by Sympathetic Withdrawal During Propofol Induction: Temporal Response Assessed by Wavelet-Based Spectral Analysis and Photoplethysmography. Frontiers in Physiology, 705153. *co-correspondence
11.Yuan-Hung Pong, Yi-Kai Chang, Ching-En Hsu, Po-Cheng Chen, Yu-Chuan Lu, Vincent F. S. Tsai, Hong-Chiang Chang, Men-Tzung Lo, Chen Lin* (2021). Probing penile hemodynamics by using photoplethysmography as objective indicators for male erection quality and sexual function. Scientific Reports, 12019. *correspondence
12.Hung-Hsun Chen, Chen Lin, Hsiang-Chih Chang, Jen-Ho Chang, Hai-Hua Chuang, Yu-Hsuan Lin (2024) Developing Methods for Assessing Mental Activity Using Human-Smartphone Interactions: Comparative Analysis of Activity Levels and Phase Patterns in General Mental Activities, Working Mental Activities, and Physical Activities. Journal of Medical Internet Research, 26:e56144
13.Huey-Wen Liang, Chueh-Hung Wu, Chen Lin, Hsiang-Chih Chang, Yu-Hsuan Lin, Shao-Yu Chen,Wei-Chen Hsu (2024) Rest-Activity Rhythm Differences in Acute Rehabilitation Between Poststroke Patients and Non–Brain Disease Controls: Comparative Study. Journal of Medical Internet Research, 26:e49530
14.Hai-Hua Chuang, Chen Lin, Li-Ang Lee, Hsiang-Chih Chang, Guan-Jie She, Yu-Hsuan Lin (2024) Comparing Human-Smartphone Interactions and Actigraphy Measurements for Circadian Rhythm Stability and Adiposity: Algorithm Development and Validation Study. Journal of Medical Internet Research, 26:e50149
15.Wei-Chih Chin, Yu-Shu Huang, Ngo Yan Trevor Lam, Ka Yu Mak, I Tang, Chih-Huan Wang, Chen Lin (2024) Effects of modafinil on nocturnal sleep patterns in patients with narcolepsy: A cohort study. Sleep Medicine, 119:95-102
16.Tzu-Fu Yeh, Chen Lin, Huang-Chih Sung (2023) A review of technological developments in lipid nanoparticle application for mRNA vaccination. Human Vaccines and Immunotherapeutics, 19(2):2256040
17.Chin-Yu Lin, Chia-Hsin Chiang, Abigail Louise D Te, Yenn-Jiang Lin, Men-Tzung Lo, Chen Lin, Shih-Lin Chang, Li-Wei Lo, Yu-Feng Hu, Fa-Po Chung, Ta-Chuan Tuan, Tze-Fan Chao, Jo-Nan Liao, Shih-Ann Chen (2023) Characterization and identification of atrial fibrillation drivers in patients with nonparoxysmal atrial fibrillation using simultaneous amplitude frequency electrogram transform. Journal of Cardiovascular Electrophysiology, 3(34),536-545.
18.Chin-Yu Lin, Yenn-Jiang Lin, Satoshi Higa, Wen-Chin Tsai, Men-Tzung Lo, Chia-Hsin Chiang, Shih-Lin Chang, Li-Wei Lo, Yu-Feng Hu, Tze-Fan Chao, Fa-Po Chung, Jo-Nan Liao, Ting-Yung Chang, Chen Lin, Ta-Chuan Tuan, Ling Kuo, Cheng-I Wu, Chih-Min Liu, Shin-Huei Liu, Ming-Jen Kuo, Ying-Chieh Liao, Chieh-Mao Chuang, Yun-Yu Chen, Yu-Cheng Hsieh, Shih-Ann Chen (2023) Catheter ablation with morphologic repetitiveness mapping for persistent atrial fibrillation. JAMA network open, 6(11):e2344535
19.Yu-Shu Huang, I Tang, Wei-Chih Chin, Ling-Sheng Jang, Chin-Pang Lee, Chen Lin, Chun-Pai Yang, Shu-Ling Cho (2022) The Subjective and Objective Improvement of Non-Invasive Treatment of Schumann Resonance in Insomnia—A Randomized and Double-Blinded Study. Nature and Science of Sleep, (14):1113-1124
20.Hsin Yi Wang, Jing Yang Liou, Chen Lin, Chien Kun Ting, Wen Kuei Chang, Men Tzung Lo, Chien Chang Chen (2022) Thermodynamic Interpretation of a Machine-Learning-Based Response Surface Model and Its Application to Pharmacodynamic Synergy between Propofol and Opioids. Mathematics, 10(10), 1651
21.Hsin-Yi Wang, Chen Lin, Chien-Chang Chen, Wei-Nung Teng, Kun-Hui Chen, Men-Tzung Lo, Chien-Kun Ting (2022) Improvement in vocal-cord visualization with Trachway video intubating stylet using direct oxygen flow and effective analysis of the fraction of inspired oxygen: a bench study. Journal of Clinical Monitoring and Computing, 36:1723–1730
22.Li-Ting Ho, Bess Ma Fabinal Serafico, Ching-En Hsu, Zhao-Wei Chen, Tse-Yu Lin, Chen Lin, Lian-Yu Lin, Men-Tzung Lo, Kuo-Liong Chien (2022) Preserved Electroencephalogram Power and Global Synchronization Predict Better Neurological Outcome in Sudden Cardiac Arrest Survivors. Frontiers in Physiology, 13:866844
23.Yi-Chia Wei, Chih-Chin Heather Hsu, Wen-Yi Huang, Yao-Liang Chen, Chemin Lin, Chih-Ken Chen, Chen Lin, Yu-Chiau Shyu, Ching-Po Lin (2021) White Matter Integrity Underlies the Physical-Cognitive Correlations in Subjective Cognitive Decline. Frontiers in Aging Neuroscience, 13:700764
24.Hui-Wen Yang, Marta Garaulet, Peng Li, Cristina Bandin, Chen Lin, Men-Tzung Lo and Kun Hu (2021) Daily rhythm of fractal cardiac dynamics links to weight loss resistance: interaction with clock 3111t/c genetic variant. Nutrients, 13(7):2463
25.Chin-Yu Lin, Yenn-Jiang Lin, Men-Tzung Lo, Chia-Hsin Chiang, Yun-Yu Chen, Ling Kuo, Shih-Lin Chang, Li-Wei Lo, Yu-Feng H, Tze-Fan Chao, Fa-Po Chung, Jo-Nan Liao, Ting-Yung Chang, Chen Lin, Ta-Chuan Tuan, Cheng-I Wu, Chih-Min Liu, Shin-Huei Liu, Wen-Han Cheng, Isaiah C Lugtu, Ankit Jain, An Nu-Khanh Ton, Dony Yugo Hermanto, Shih-Ann Chen (2021) Efficacy of Patient-Specific Strategy: Catheter Ablation Strategy of Persistent Atrial Fibrillation Based on Morphological Repetitiveness by Periodicity and Similarity. Circulation: Arrhythmia and Electrophysiology, 5(14): e009719
26.Shu-Yu Tang, Hsi-Pin Ma, Chi-Sheng Hung, Ping-Hung Kuo, Chen Lin, Men-Tzung Lo, Hsao-Hsun Hsu, Yu-Wei Chiu, Cho-Kai Wu, Cheng-Hsuan Tsai, Yen-Tin Lin, Chung-Kang Peng, Yen-Hung Lin (2021) The value of heart rhythm complexity in identifying high-risk pulmonary hypertension patients. Entropy, 6(23):753
27.Yu-Cheng Hsieh, Yenn-Jiang Lin, Men-Tzung Lo, Yun-Yu Chen, Chin-Yu Lin, Chen Lin, Fa-Po Chung, Li-Wei Lo, Shih-Lin Chang, Tze-Fan Chao, Yu-Feng Hu, Ta-Chuan Tuan, Jo-Nan Liao, Cheng-I Wu, Chih-Min Liu, Jennifer-Jeanne B Vicera, Chun-Chao Chen, Chye-Gen Chin, Isaiah C Lugtu, Ankit Jain, An Nu-Khanh Ton, Dony Yugo Hermanto, Shih-Ann Chen (2021) Efficacy of Patient-Specific Strategy: Catheter Ablation Strategy of Persistent Atrial Fibrillation Based on Morphological Repetitiveness by Periodicity and Similarity. Circulation Arrhythmia Electrophysiology, 14(5):e009719
28.Jien-Jiun Chen, Chen Lin, Wen-Pin Hsiao, Tai-Min Chu, Hui-Wen Yang, Men-Tzung Lo, Lian-Yu Lin, Shien-Fong Lin (2021) Complex dynamics of skin sympathetic nerve activities as a prognostic predictor for critically ill patients. Journal of the Formosan Medical Association, 120(1): 660-667
29.Cheng-Hsuan Tsai, Hsi-Pin Ma, Yen-Tin Lin, Chi-Sheng Hung, Shan-Hsuan Huang, Bei-Lin Chuang, Chen Lin, Men-Tzung Lo, Chung-Kang Peng, Yen-Hung Lin (2020) Usefulness of heart rhythm complexity in heart failure detection and diagnosis. Scientific Reports,1(10):14916
30.Pham V-T, Lin C*, Tran T-T, Su M-Y M., Lin Y-K, Nien C-T, Tseng W-Y I., Lin J-L, Lo M-T, Lin L-Y, Predicting ventricular tachyarrhythmia in patients with systolic heart failure based on texture features of the gray zone from contrast-enhanced magnetic resonance imaging. Journal of Cardiology, 2020, S0914-5087(20)30222-7 (*corresponding author)
Lin C, Lin P-F, Wang C-H, Juan C-H, Tran T-T, Nien C-T, Lin YJ, Wang C.Y., Yeh CH, and Lo MT, Probing age-related changes in cardio-respiratory dynamics by multimodal coupling assessment. Chaos, 2020, 30:033118
31.Lin Y-K, Kao C-C, Tseng C-H, Hsu C-E, Lin Y-J, Chen Y-C, Lin C*, and C-Y Huang, Noninvasive Hemodynamic Profiles during Hemodialysis in Patients with and without Heart Failure. Cardiorenal Medicine, 2020,10(4):243-256 (*corresponding author)
32.Lin C, Wong B-Y, Lo M-T, Chiu Y-C, and Lin Y-H, Development of an addiction index and delineation 15-year trends of illicit drugs from a nationwide drug enhancement database. Journal of Psychiatric Research, 2020, 120(1):131-136
33.Kao C-C, Tseng C-H, Lo M-T, Lin Y-K, Hsu C-Y, Wu Y-L, Chen H-H, Lin F-Y, C Lin*, and C-Y Huang Alteration autonomic control of cardiac function during hemodialysis predict cardiovascular outcomes in end stage renal disease patients Scientific Reports, 2019, 9:18783 (*corresponding author)
34.Tseng C-H, Lin C*, Chang H-C, Liu C-C, Serafico BMF, Wu L-C, Lin C-T, Hsu T, Huang C-Y, and M-T Lo Cloud-Based Artificial Intelligence System for Large-Scale Arrhythmia Screening Computer, 2019, 52(11):40-51 (*corresponding author)
35.Lin C*, Yeh C-H, Wang C-Y, Shi W, Serafico BMF, Wang C-H, Juan C-H, Young H-W Vincent, Lin Y-J, Yeh H-M, and Lo M-T, Robust Fetal Heart Beat Detection via R-peak Intervals Distribution. IEEE Transactions on Biomedical Engineering, 2019, 66(12):3310-3319 (* corresponding author)
36.Tsai C-H, Ma H-P, Lin Y-T, Hung C-S, Hsieh M-C, Chang T-Y, Kuo P-H, Lin C*, Lo M-T, Hsu H-H, Peng C-K, and Lin Y-H, Heart Rhythm Complexity Impairment in Patients with Pulmonary Hypertension, Scientific Reports, 2019, 9:10710 (*corresponding author)
37.Lin C, Lo M-T, and Guilleminault C, Exploring the abnormal modulation of the autonomic systems during nasal flow limitation in upper airway resistance syndrome by Hilbert–Huang transform. Frontiers in Medicine, 2017, 4(161)
38.Lin C, Chang Y-C, Cheng Y-C, Lai P-J, Yeh C-H, Hsieh W-H, Hu K, Wu J-T, Lee H-H, M-T Lo, and Y-L Ho, Probing the fractal pattern of heartbeats in Drosophila pupae by visible optical recording system Scientific Reports, 2016, 6: 31950
39.Tsai C-H, Huang J-W, Lin C., Ma H-P, Lo M-T, Liiu L-YD, Lin L-Y, Lin C-T, Hung C-S, Peng C-K, and Lin Y-H Heart Rhythm Complexity Predicts Long‐Term Cardiovascular Outcomes in Peritoneal Dialysis Patients: A Prospective Cohort Study. Journal of the American Heart Association, 2020, 9(2):e013036
40.Tran T-T, Pham V-T, Lin C, Yang HW, Wang YH, Shyu KK, Tseng WYI, Su MY, Lin LY, Lo M-T, “Empirical Mode Decomposition and Monogenic Signal-Based Approach for Quantification of Myocardial Infarction From MR Images” IEEE Journal of Biomedical and Health Informatics 2018,23(2):731-743
41.Yeh C-H, Juan C-H, Yeh H-M, Wang C.Y. Young H-WV, Lin J-L, Lin C, Lin L-Y, and Lo M-T The critical role of respiratory sinus arrhythmia on temporal cardiac dynamics. Journal of Applied Physiology, 2019, 127(6):1733-1741
42.Tran TT, Fang TY, Pham VT, Lin C, Wang PC, and Lo M-T, “Development of an Automatic Diagnostic Algorithm for Pediatric Otitis Media”, Otology & Neurotology, 2018 Sep;39(8):1060-1065.
43.Yang HW, Jeng SK, Young HWV, Lin C, Wang YH, Hu K, and Lo M-T, “A Minimum Arclength Method for Removing Spikes in Empirical Mode Decomposition”, IEEE ACCESS, 2019, 7:13284
44.Gao L, Li P, Hu C, To T, Patxot M, Falvey B, Wong PM, Scheer FAJL, Lin C, Lo MT,and Hu K “Nocturnal Heart Rate Variability Moderates the Association Between Sleep-Wake Regularity and Mood in Young Adults.” Sleep, 2019, 42(5)
45.Y.-H. Lin, M.-T. Lo, X.-M. Wu, C.-S. Hung, Y.-L. Ho, K.-D. Wu, C. Lin*, V.-C. Wu, M. Stowasser, C.-K. Peng and the TAIPAI Study Group “Adrenalectomy reverses the impaired heart rhythm complexity in patients with primary aldosteronism” Scientific Reports, 2015 5:11249 (*corresponding author)
46.M.-T Lo, Y.-C. Chang, C. Lin, Vincent H.-W. Young, Y.-H. Lin, Y.-L. Ho, C.-K. Peng, K. Hu “Outlier-resilient complexity analysis of heartbeat dynamics” Scientific Reports, 2015, 5:8836
47.P.-F. Lin, J. Tsao, M.-T. Lo, C. Lin, Y.-C. Chang “Symbolic Entropy of the Amplitude rather than the Instantaneous Frequency of EEG Varies in Dementia”, Entropy, 2015 Jan; 17(2): 560-579
Ministry of Science and Technology
2022-2025 Developing a portable, multi-modal device for cardiac function monitoring and a cloud-based system for the precision care of high-risk patients with cardiovascular disease.
2021-2022 Building Circadian Rhythm Prediction Model across Multiple Diseases from Long-term Continuous Physiological Signals-A Bench-to-Bedside Study
2019-2021 A Multi-Signal Based Automated Monitoring System for Pediatric Sleep Disorders
2017 Industry-Academy cooperation project of Hsinchu Science Park Bureau-“An integrated platform for early screening of sleep breathing disorders.”
2014-2017 Realization of a wearable device for biomarker detection and cloud computation based feedback (Subproject 3 : Exploiting biomarkers of physiological signals recorded from wearable devices by using adaptive data analysis)
Social Responsibility and Community Service
2022 – Partnered with the Rotary Club of Taipei Grand Park to organize atrial fibrillation screening for the elderly population in Taoyuan City.
2017–2021 – Collaborated with the Department of Public Health, Taoyuan City, to conduct atrial fibrillation screening during community cancer screening programs.
Joint Research Grants
2017 Joint Project of National Central University and Landseed Hospital-Exploring the associations among in-patient longitudinal changes of vital signs, laboratory data of acute exacerbations of chronic obstructive pulmonary disease and their prognosis by machine learning.”
Patent
- 1. Method and system for extracting ventricular fibrillation signals in electrocardiogram using spline interpolation with uniform phase ensembles US 9451898 B2 Sep, 2016
- 2. System and method for quantitative analysis of respiratory sinus arrhythmia US 9380948 B1 Jul, 2016
- 3. Method and system for extracting ventricular fibrillation signals in electrocardiogram, US 9259167 B2 Feb, 2016
Last Updated: 2025-08-14