馬念涵教授
發布日期： 2024-05-16
Nianhan Ma
專長：微型RNA應用、疾病偵測指標、新型藥物研發、腫瘤治療、體液胞外小體
連絡電話：03-4227151轉36112
E-mail：nianhan.ma@g.ncu.edu.tw
個人網站：https://in.ncu.edu.tw/~ncu36113/ch.news.html
Education
Ph.D. Department of Pathology, Yale University, USA
M.S. Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, USA
M.S. Department of Biochemistry, National Taiwan University, Taiwan
B.S. Department of Botany, National Chung Hsing University, Taiwan
Professional Honors and Recognition
2021 第18屆國家新創獎-學研新創獎
https://reurl.cc/QLDk9o
2021 Sliver Award, Taiwan Innotech Expo (台灣創新技術博覽會發明競賽銀牌獎)
2021 Creative inventor of Taoyuan (桃園市創意發明家)
2020 Platinum Award, Taiwan Innotech Expo (台灣創新技術博覽會發明競賽鉑金獎)
2017-2021 Excellent Research Award, National Central University, Taiwan
Peer-reviewed Journals (past 5 years)
(Ma lab members in bold: graduate students#; postdocs†)
1.Nguyen MT#, Luo YH, Li AL#, Tsai JC#, Wu KL#, Chung PJ, Ma N*, miRNA as a modulator of immunotherapy and immune response in melanoma, Biomolecules, 2021, (11), 1648. doi: 10.3390/biom11111648. Invited Review article
2.Li AL#, Chou CY, Chen CL, Wu KL#, Lin SC, Chen HC, Wang MC, Chang CC, Hsu BG, Wu MS, Ma N*, Huang CC*, The microRNA prediction models as ancillary diagnosis biomarkers for urothelial carcinoma in patients with chronic kidney disease, Front Med.(Lausanne), 2021, 8, 726214, doi: 10.3389/fmed.2021.726214. [JCR:Q1]
3.Thi Nguyen M#, Lin CH†, Liu SM#, Miyashita A, Ihn H, Lin H, Ng CH, Tsai JC#, Chen MH, Tsai MS, Lin IY#, Liu SC, Li LY, Fukushima S *, Lu J*, Ma N* , miR-524-5p reduces the progression of the BRAF inhibitor-resistant melanoma, Neoplasia, 2020, 22(12):789-799 [JCR:Q1]
4.Cheng CL ,Yang SC, Lai CY, Wang CK, Chang CF, Lin CY, Chen WJ, Lin PY, Wu HC, Ma N, Lu FL, Lu J, CXCL14 Maintains hESC Self-Renewal through Binding to IGF-1R and Activation of the IGF-1R Pathway, Cells, 2020 Jul 16;9(7):1706. doi: 10.3390/cells9071706.
5.Chen CL#, Lin CH†, Li AL#, Huang CC, Shen BY, Chiang YU#, Fang PL#, Chang HC, Li, KL, Yang WC, Horng JT*, Ma N*, Plasma MicroRNA Profile is a Biomarker Associated with Urothelial Carcinoma in Chronic Hemodialysis Patients, Am J physiol Renal physiol, 2019,316(6):F1094-F1102 [JCR:Q1]
6.Lin IY#, Chiou YS, Wu LC, Tsai CY, Chen CT, Chuang WC, Lee MC, Lin CC, Lin TT#, Chen SC, Pan MH*, Ma N*, CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-β, Wnt and STAT3 signaling pathways, Journal of Food And Drug Analysis, 2019, 27(1):184-194 [JCR:Q1]
7.Li AL#, Chung TS, Chan YN#, Chen CL#, Lin SC, Chiang YU#, Lin CH#, Chen CC, Ma N*, microRNA expression pattern as an ancillary prognostic signature for radiotherapy, Journal of Translational medicine, 2018,16 (1): 341 [JCR:Q1]
8.Liu SM#, Lin CH†, Lu J, Lin IY#, Tsai MS, Chen MH and Ma N*, miR-596 modulates melanoma growth by regulating cell survival and death, Journal of Investigative Dermatology, 2018, 138(4), 911-921 [JCR:Q1]
9.Chen WY, Ma N, Li TL, Su LJ, Chang YH, MicroRNA in situ hybridization with phosphate-methylated oligonucleotides (nDNA) probe, New Biotechnology, 2018, 44, S147 [JCR:Q1]
10.Lin IY#, Pan MH, Lai CS, Lin TT#, Chen CT, Chung TS, Chen CL, Lin CH†, Chuang WC, Lee MC, Lin CC, Ma N*, CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-κB pathways, Scientific Reports, 2017, 7(1):4862. [JCR:Q1]
11.Hsu C-L, Chung F-H, Chen C-H, Hsu T-T, Liu S-M#, Chung D-S, Hsu Y-F, Chen CL#, Ma N* and Lee H-C*, Genotypes of cancer stem cells characterized by epithelial-to-mesenchymal transition and proliferation related functions, (* Co-corresponding Author), Scientific Reports, 2016, 6:32523. [JCR:Q1]
12.Yen C-I, Liu SM#, Lo W-S , Wu J-W, Liu Y-H, Chein R-J, Yang R, Ma N* and Shieh F-K*, Cytotoxicity of Postmodified Zeolitic-Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity, (* Co-corresponding Author), Chemistry - A European Journal, 2016, 22(9):2925-9 [JCR:Q1]
Patent
1.Ma N, Chang CH, Chen JB, Tseng CC, Wang IK, Chen CL, Li AL; 在腹膜透析病患中由腹腔液偵測microRNA預測腹膜硬化症之方法/ Method for estimating a risk for a subject suffering from encapsulating peritoneal sclerosis, analyzer and kit thereof; Taiwan, I740533, 2021/9/21-2040/6/10; US, 16/924,793 (applying); China 202010527704.X (applying)
2.Ma N, Chen CL, Lin CH, Li AL, Huang, CC, Chang CH, 泌尿上皮癌的檢測套組及檢測方法 / Detection Kit And Detection Method For Urothelial Carcinoma; Taiwan, I690597, 2020/04/01-2038/11/13; US 11,098,371, 2021/8/24-2039/9/3; China 201910299262.5 (applying)
3.Ma N, Huang, CC, Chang CH, Chen CL, Li AL; 評估個體罹患泌尿上皮癌之風險的方法及其套組/ Method for estimating a risk for a subject suffering from urothelial carcinoma and kit thereof; Taiwan, I718474, 2021/02/11-2039/01/30; US, 16/658,754 (applying) ; China 201910126024.4 (applying)
4.Ma N, Chung TS, Chan YN, Chen CL, Li AL; 預測癌症放射線治療之預後的分析器及方法/ Analyzer and analytical method for predicting the prognosis of cancer radiotherapy; Taiwan, I614629, 2018/2-2037/2; US 10,738,363 B2, 2017/08/30-2037/08/30
5.Ma N, Lin CH, Su HH, Chen CH, Glucose dehydrogenase and method for producing the dehydrogenase; US#62/192,074
Conference
1.Pham HT, Li AL, Lin SY, Chung TS, Wang MH, Ma N*, miR-148a-3p expression induces radiosensitivity and reduces bystander effects in head and neck cancer cells, The 36th Joint Annual Conference of Biomedical Science, Taipei, Taiwan, March 25, 2022.
2.Wu PJ, Tsai JC, Wu KL, Chen CT, Ma N＊, Tamoxifen reduces high glucose-induced mesothelial- to-mesenchymal transition, The 36th Joint Annual Conference of Biomedical Science , Taipei, Taiwan, March 25, 2022.
3.Lin CY, Chung PJ, Thi Nguyen M, Ma N*, BRAF inhibitor-induced tumorigenesis via extracellular vesicles in the tumor microenvironment, The 36th Joint Annual Conference of Biomedical Science, Taipei, Taiwan, March 25, 2022.
4.Tsai JC, Wu KL, Yang JL, Ma N*, Chen CT*, MicroRNAs Involved in Peritoneal Fibrosis, 2022 The 36th Joint Annual Conference of Biomedical Science, Online, Taiwan, Mar. 25, 2022.
5.Tsai JC, Lin CH, Liu H, Chen CT, Ma N*, The miRNA profile as an ancillary diagnosis biomarker for coronary artery disease, International Symposium on Evolutionary Genomics and Bioinformatics 2022, Taipei, Taiwan, Mar. 12-13, 2022.
6.Chung PJ, Chen CL, Luo HL, Wu KL, Tsai JC, Wu PJ, Li AL, Fung YC, Ma N*, The microRNA classifiers as ancillary diagnosis biomarkers of urothelial carcinoma for dialysis patients, International Symposium on Evolutionary Genomics and Bioinformatics, Taipei, Taiwan, Mar 12-13, 2022
7.Tsai JC, Huang CY, Yang JL, Ma N*, Chen CT*, Methylglyoxal induces peritoneal fibrosis and angiogenesis in rat peritoneal dialysis model, 14th Asia Pacific Federation of Pharmacologists, Taipei, Taiwan, Nov. 26-29, 2021.
專長：微型RNA應用、疾病偵測指標、新型藥物研發、腫瘤治療、體液胞外小體
連絡電話：03-4227151轉36112
E-mail：nianhan.ma@g.ncu.edu.tw
個人網站：https://in.ncu.edu.tw/~ncu36113/ch.news.html
Education
Ph.D. Department of Pathology, Yale University, USA
M.S. Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, USA
M.S. Department of Biochemistry, National Taiwan University, Taiwan
B.S. Department of Botany, National Chung Hsing University, Taiwan
Professional Honors and Recognition
2021 第18屆國家新創獎-學研新創獎
https://reurl.cc/QLDk9o
2021 Sliver Award, Taiwan Innotech Expo (台灣創新技術博覽會發明競賽銀牌獎)
2021 Creative inventor of Taoyuan (桃園市創意發明家)
2020 Platinum Award, Taiwan Innotech Expo (台灣創新技術博覽會發明競賽鉑金獎)
2017-2021 Excellent Research Award, National Central University, Taiwan
Peer-reviewed Journals (past 5 years)
(Ma lab members in bold: graduate students#; postdocs†)
1.Nguyen MT#, Luo YH, Li AL#, Tsai JC#, Wu KL#, Chung PJ, Ma N*, miRNA as a modulator of immunotherapy and immune response in melanoma, Biomolecules, 2021, (11), 1648. doi: 10.3390/biom11111648. Invited Review article
2.Li AL#, Chou CY, Chen CL, Wu KL#, Lin SC, Chen HC, Wang MC, Chang CC, Hsu BG, Wu MS, Ma N*, Huang CC*, The microRNA prediction models as ancillary diagnosis biomarkers for urothelial carcinoma in patients with chronic kidney disease, Front Med.(Lausanne), 2021, 8, 726214, doi: 10.3389/fmed.2021.726214. [JCR:Q1]
3.Thi Nguyen M#, Lin CH†, Liu SM#, Miyashita A, Ihn H, Lin H, Ng CH, Tsai JC#, Chen MH, Tsai MS, Lin IY#, Liu SC, Li LY, Fukushima S *, Lu J*, Ma N* , miR-524-5p reduces the progression of the BRAF inhibitor-resistant melanoma, Neoplasia, 2020, 22(12):789-799 [JCR:Q1]
4.Cheng CL ,Yang SC, Lai CY, Wang CK, Chang CF, Lin CY, Chen WJ, Lin PY, Wu HC, Ma N, Lu FL, Lu J, CXCL14 Maintains hESC Self-Renewal through Binding to IGF-1R and Activation of the IGF-1R Pathway, Cells, 2020 Jul 16;9(7):1706. doi: 10.3390/cells9071706.
5.Chen CL#, Lin CH†, Li AL#, Huang CC, Shen BY, Chiang YU#, Fang PL#, Chang HC, Li, KL, Yang WC, Horng JT*, Ma N*, Plasma MicroRNA Profile is a Biomarker Associated with Urothelial Carcinoma in Chronic Hemodialysis Patients, Am J physiol Renal physiol, 2019,316(6):F1094-F1102 [JCR:Q1]
6.Lin IY#, Chiou YS, Wu LC, Tsai CY, Chen CT, Chuang WC, Lee MC, Lin CC, Lin TT#, Chen SC, Pan MH*, Ma N*, CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-β, Wnt and STAT3 signaling pathways, Journal of Food And Drug Analysis, 2019, 27(1):184-194 [JCR:Q1]
7.Li AL#, Chung TS, Chan YN#, Chen CL#, Lin SC, Chiang YU#, Lin CH#, Chen CC, Ma N*, microRNA expression pattern as an ancillary prognostic signature for radiotherapy, Journal of Translational medicine, 2018,16 (1): 341 [JCR:Q1]
8.Liu SM#, Lin CH†, Lu J, Lin IY#, Tsai MS, Chen MH and Ma N*, miR-596 modulates melanoma growth by regulating cell survival and death, Journal of Investigative Dermatology, 2018, 138(4), 911-921 [JCR:Q1]
9.Chen WY, Ma N, Li TL, Su LJ, Chang YH, MicroRNA in situ hybridization with phosphate-methylated oligonucleotides (nDNA) probe, New Biotechnology, 2018, 44, S147 [JCR:Q1]
10.Lin IY#, Pan MH, Lai CS, Lin TT#, Chen CT, Chung TS, Chen CL, Lin CH†, Chuang WC, Lee MC, Lin CC, Ma N*, CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-κB pathways, Scientific Reports, 2017, 7(1):4862. [JCR:Q1]
11.Hsu C-L, Chung F-H, Chen C-H, Hsu T-T, Liu S-M#, Chung D-S, Hsu Y-F, Chen CL#, Ma N* and Lee H-C*, Genotypes of cancer stem cells characterized by epithelial-to-mesenchymal transition and proliferation related functions, (* Co-corresponding Author), Scientific Reports, 2016, 6:32523. [JCR:Q1]
12.Yen C-I, Liu SM#, Lo W-S , Wu J-W, Liu Y-H, Chein R-J, Yang R, Ma N* and Shieh F-K*, Cytotoxicity of Postmodified Zeolitic-Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity, (* Co-corresponding Author), Chemistry - A European Journal, 2016, 22(9):2925-9 [JCR:Q1]
Patent
1.Ma N, Chang CH, Chen JB, Tseng CC, Wang IK, Chen CL, Li AL; 在腹膜透析病患中由腹腔液偵測microRNA預測腹膜硬化症之方法/ Method for estimating a risk for a subject suffering from encapsulating peritoneal sclerosis, analyzer and kit thereof; Taiwan, I740533, 2021/9/21-2040/6/10; US, 16/924,793 (applying); China 202010527704.X (applying)
2.Ma N, Chen CL, Lin CH, Li AL, Huang, CC, Chang CH, 泌尿上皮癌的檢測套組及檢測方法 / Detection Kit And Detection Method For Urothelial Carcinoma; Taiwan, I690597, 2020/04/01-2038/11/13; US 11,098,371, 2021/8/24-2039/9/3; China 201910299262.5 (applying)
3.Ma N, Huang, CC, Chang CH, Chen CL, Li AL; 評估個體罹患泌尿上皮癌之風險的方法及其套組/ Method for estimating a risk for a subject suffering from urothelial carcinoma and kit thereof; Taiwan, I718474, 2021/02/11-2039/01/30; US, 16/658,754 (applying) ; China 201910126024.4 (applying)
4.Ma N, Chung TS, Chan YN, Chen CL, Li AL; 預測癌症放射線治療之預後的分析器及方法/ Analyzer and analytical method for predicting the prognosis of cancer radiotherapy; Taiwan, I614629, 2018/2-2037/2; US 10,738,363 B2, 2017/08/30-2037/08/30
5.Ma N, Lin CH, Su HH, Chen CH, Glucose dehydrogenase and method for producing the dehydrogenase; US#62/192,074
Conference
1.Pham HT, Li AL, Lin SY, Chung TS, Wang MH, Ma N*, miR-148a-3p expression induces radiosensitivity and reduces bystander effects in head and neck cancer cells, The 36th Joint Annual Conference of Biomedical Science, Taipei, Taiwan, March 25, 2022.
2.Wu PJ, Tsai JC, Wu KL, Chen CT, Ma N＊, Tamoxifen reduces high glucose-induced mesothelial- to-mesenchymal transition, The 36th Joint Annual Conference of Biomedical Science , Taipei, Taiwan, March 25, 2022.
3.Lin CY, Chung PJ, Thi Nguyen M, Ma N*, BRAF inhibitor-induced tumorigenesis via extracellular vesicles in the tumor microenvironment, The 36th Joint Annual Conference of Biomedical Science, Taipei, Taiwan, March 25, 2022.
4.Tsai JC, Wu KL, Yang JL, Ma N*, Chen CT*, MicroRNAs Involved in Peritoneal Fibrosis, 2022 The 36th Joint Annual Conference of Biomedical Science, Online, Taiwan, Mar. 25, 2022.
5.Tsai JC, Lin CH, Liu H, Chen CT, Ma N*, The miRNA profile as an ancillary diagnosis biomarker for coronary artery disease, International Symposium on Evolutionary Genomics and Bioinformatics 2022, Taipei, Taiwan, Mar. 12-13, 2022.
6.Chung PJ, Chen CL, Luo HL, Wu KL, Tsai JC, Wu PJ, Li AL, Fung YC, Ma N*, The microRNA classifiers as ancillary diagnosis biomarkers of urothelial carcinoma for dialysis patients, International Symposium on Evolutionary Genomics and Bioinformatics, Taipei, Taiwan, Mar 12-13, 2022
7.Tsai JC, Huang CY, Yang JL, Ma N*, Chen CT*, Methylglyoxal induces peritoneal fibrosis and angiogenesis in rat peritoneal dialysis model, 14th Asia Pacific Federation of Pharmacologists, Taipei, Taiwan, Nov. 26-29, 2021.
更新日期: 2024-05-24