welcome to Department of Biomedical Sciences & Engineering.

Faculties in Systems Biology and Bioinformatics

Associate Professor Yi-Chiung Hsu

Posted on: 2021-06-08
專長:Biological and Medical Data Analysis,bioinformatics , Artificial intelligence in clinical and genomic diagnostics

國立陽明大學藥理學研究所 博士
台北醫學大學藥學系 學士
中研院統計所     博士後研究員   
中國文化大學/園藝暨生物技術學系 兼任助理教授
台灣大學/內科    博士後研究員
台灣師範大學/生命科學系 兼任助理教授

著作目錄 Publications
1. Lee JJ, Hsu YC, Li YS and Cheng SP. Galectin-3 Inhibitors Suppress Anoikis Resistance and Invasive Capacity in Thyroid Cancer Cells. International journal of endocrinology. 2021; 2021:5583491.
2. Raghav L, Chang YH, Hsu YC, Li YC, Chen CY, Yang TY, Chen KC, Hsu KH, Tseng JS, Chuang CY, Lee MH, Wang CL, Chen HW, et al. Landscape of Mitochondria Genome and Clinical Outcomes in Stage 1 Lung Adenocarcinoma. Cancers. 2020; 12(3).
3. Liu CL, Hsu YC, Lee JJ, Chen MJ, Lin CH, Huang SY and Cheng SP. Targeting the pentose phosphate pathway increases reactive oxygen species and induces apoptosis in thyroid cancer cells. Molecular and cellular endocrinology. 2020; 499:110595.
4. Leu YL, Wang TH, Wu CC, Huang KY, Jiang YW, Hsu YC and Chen CY. Hydroxygenkwanin Suppresses Non-Small Cell Lung Cancer Progression by Enhancing EGFR Degradation. Molecules (Basel, Switzerland). 2020; 25(4).
5. Chen JY, Wang JJ, Lee HC, Chi CW, Lee CH and Hsu YC. Combination of peroxisome proliferator-activated receptor gamma and retinoid X receptor agonists induces sodium/iodide symporter expression and inhibits cell growth of human thyroid cancer cells. Journal of the Chinese Medical Association : JCMA. 2020; 83(10):923-930.
6. Chen CC, Wong TY, Chin TY, Lee WH, Kuo CY and Hsu YC. Systems biology approach to exploring the effect of cyclic stretching on cardiac cell physiology. Aging. 2020; 12(16):16035-16045.
7. Chang CL, Wu CC, Hsu YT and Hsu YC. Immune vulnerability of ovarian cancer stem-like cells due to low CD47 expression is protected by surrounding bulk tumor cells. Oncoimmunology. 2020; 9(1):1803530.
8. Yang PS, Liu CP, Hsu YC, Chen CF, Lee CC and Cheng SP. A Novel Prediction Model for Bloodstream Infections in Hepatobiliary-Pancreatic Surgery Patients. World journal of surgery. 2019; 43(5):1294-1302.
9. Sung YC, Jin PR, Chu LA, Hsu FF, Wang MR, Chang CC, Chiou SJ, Qiu JT, Gao DY, Lin CC, Chen YS, Hsu YC, Wang J, et al. Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies. Nature nanotechnology. 2019; 14(12):1160-1169.
10. Huang YC, Lee PC, Wang JJ and Hsu YC. Anticancer Effect and Mechanism of Hydroxygenkwanin in Oral Squamous Cell Carcinoma. Frontiers in oncology. 2019; 9:911.
11. Hsu YC, Lee JJ, Chien MN, Chen MJ, Leung CH and Cheng SP. Is papillary thyroid microcarcinoma a biologically different disease? A propensity score-matched analysis. Journal of surgical oncology. 2019; 120(6):1023-1030.
12. Hsu YC, Chang YH, Chang GC, Ho BC, Yuan SS, Li YC, Zeng JW, Yu SL, Li KC, Yang PC and Chen HY. Tumor mutation burden and recurrent tumors in hereditary lung cancer. Cancer medicine. 2019; 8(5):2179-2187.
13. Yang PS, Hsu YC, Lee JJ, Chen MJ, Huang SY and Cheng SP. Heme Oxygenase-1 Inhibitors Induce Cell Cycle Arrest and Suppress Tumor Growth in Thyroid Cancer Cells. International journal of molecular sciences. 2018; 19(9).
14. Yang PS, Hsu HH, Hsu TC, Chen MJ, Wang CD, Yu SL, Hsu YC and Li KC. Genome-Wide Scan for Copy Number Alteration Association with Relapse-Free Survival in Colorectal Cancer with Liver Metastasis Patients. Journal of clinical medicine. 2018; 7(11).
15. Tsai CC, Yang PS, Liu CL, Wu CJ, Hsu YC and Cheng SP. Comparison of topical mupirocin and gentamicin in the prevention of peritoneal dialysis-related infections: A systematic review and meta-analysis. American journal of surgery. 2018; 215(1):179-185.
16. Hsu CY, Chang GC, Chen YJ, Hsu YC, Hsiao YJ, Su KY, Chen HY, Lin CY, Chen JS, Chen YJ, Hong QS, Ku WH, Wu CY, et al. FAM198B Is Associated with Prolonged Survival and Inhibits Metastasis in Lung Adenocarcinoma via Blockage of ERK-Mediated MMP-1 Expression. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018; 24(4):916-926.
17. Chien MN, Yang PS, Hsu YC, Liu TP, Lee JJ and Cheng SP. Transcriptome analysis of papillary thyroid cancer harboring telomerase reverse transcriptase promoter mutation. Head & neck. 2018; 40(11):2528-2537.
18. Lee JJ, Wang TY, Liu CL, Chien MN, Chen MJ, Hsu YC, Leung CH and Cheng SP. Dipeptidyl Peptidase IV as a Prognostic Marker and Therapeutic Target in Papillary Thyroid Carcinoma. The Journal of clinical endocrinology and metabolism. 2017; 102(8):2930-2940.
19. Chien MN, Yang PS, Lee JJ, Wang TY, Hsu YC and Cheng SP. Recurrence-associated genes in papillary thyroid cancer: An analysis of data from The Cancer Genome Atlas. Surgery. 2017; 161(6):1642-1650.
20. Yang PS, Wang JJ, Wang YH, Jan WC, Cheng SP and Hsu YC. 1,6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane potentiates in vitro and in vivo antitumor effects of irinotecan on human colorectal cancer cells. Oncology letters. 2016; 11(5):3551-3557.
21.Su TJ, Ku WH, Chen HY, Hsu YC, Hong QS, Chang GC, Yu SL and Chen JJ. Oncogenic miR-137 contributes to cisplatin resistance via repressing CASP3 in lung adenocarcinoma. American journal of cancer research. 2016; 6(6):1317-1330.
22. Liu CH, Ho BC, Chen CL, Chang YH, Hsu YC, Li YC, Yuan SS, Huang YH, Chang CS, Li KC and Chen HY. ePIANNO: ePIgenomics ANNOtation tool. PloS one. 2016; 11(2):e0148321.
23. Huang P, Cheng CL, Chang YH, Liu CH, Hsu YC, Chen JS, Chang GC, Ho BC, Su KY, Chen HY and Yu SL. Molecular gene signature and prognosis of non-small cell lung cancer. Oncotarget. 2016; 7(32):51898-51907.
24. Hsu YC, Liu CL, Yang PS, Tsai CH, Lee JJ and Cheng SP. Interaction of Age at Diagnosis with Transcriptional Profiling in Papillary Thyroid Cancer. World journal of surgery. 2016; 40(12):2922-2929.
25. Hsiao YJ, Su KY, Hsu YC, Chang GC, Chen JS, Chen HY, Hong QS, Hsu SC, Kang PH, Hsu CY, Ho BC, Yang TH, Wang CY, et al. SPANXA suppresses EMT by inhibiting c-JUN/SNAI2 signaling in lung adenocarcinoma. Oncotarget. 2016; 7(28):44417-44429.
26. Yang PS, Wang JJ, Tsai TH, Wang YH, Jan WC, Cheng SP, Chi CW and Hsu YC. Anticolorectal cancer effects and pharmacokinetic application of 2, 2-Bis [4-(4-amino-3-hydroxyphenoxy) phenyl] adamantane. International journal of clinical and experimental medicine. 2015; 8(9):14805-14815.
27. Tsai MF, Chang TH, Wu SG, Yang HY, Hsu YC, Yang PC and Shih JY. EGFR-L858R mutant enhances lung adenocarcinoma cell invasive ability and promotes malignant pleural effusion formation through activation of the CXCL12-CXCR4 pathway. Scientific reports. 2015; 5:13574.
28. Cheng SP, Liu CL, Chen MJ, Chien MN, Leung CH, Lin CH, Hsu YC and Lee JJ. CD74 expression and its therapeutic potential in thyroid carcinoma. Endocrine-related cancer. 2015; 22(2):179-190.
29. Cheng SP, Lee JJ, Liu TP, Yang PS, Liu SC, Hsu YC and Liu CL. Quality of Life After Surgery or Surveillance for Asymptomatic Primary Hyperparathyroidism: A Meta-Analysis of Randomized Controlled Trials. Medicine. 2015; 94(23):e931.
30. Chen HY, Yu SL, Ho BC, Su KY, Hsu YC, Chang CS, Li YC, Yang SY, Hsu PY, Ho H, Chang YH, Chen CY, Yang HI, et al. R331W Missense Mutation of Oncogene YAP1 Is a Germline Risk Allele for Lung Adenocarcinoma With Medical Actionability. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2015; 33(20):2303-2310.
31. Ko WC, Liu CL, Lee JJ, Liu TP, Yang PS, Hsu YC and Cheng SP. Negative association between serum parathyroid hormone levels and urinary perchlorate, nitrate, and thiocyanate concentrations in U.S. adults: the National Health and Nutrition Examination Survey 2005-2006. PloS one. 2014; 9(12):e115245.
32. Cheng SP, Liu CL, Liu TP, Hsu YC and Lee JJ. Association between parathyroid hormone levels and inflammatory markers among US adults. Mediators of inflammation. 2014; 2014:709024.
33. Cheng SP, Hsu YC, Liu CL, Liu TP, Chien MN, Wang TY and Lee JJ. Significance of allelic percentage of BRAF c.1799T > A (V600E) mutation in papillary thyroid carcinoma. Annals of surgical oncology. 2014; 21 Suppl 4:S619-626.
34. Chang YC, Hsu YC, Liu CL, Huang SY, Hu MC and Cheng SP. Local anesthetics induce apoptosis in human thyroid cancer cells through the mitogen-activated protein kinase pathway. PloS one. 2014; 9(2):e89563.
35. Liu CL, Lee JJ, Liu TP, Chang YC, Hsu YC and Cheng SP. Blood neutrophil-to-lymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer. Journal of surgical oncology. 2013; 107(5):493-497.
36. Liang CH, Chiu SY, Hsu IL, Wu YY, Tsai YT, Ke JY, Pan SH, Hsu YC, Li KC, Yang PC, Chen YL and Hong TM. α-Catulin drives metastasis by activating ILK and driving an αvβ3 integrin signaling axis. Cancer research. 2013; 73(1):428-438.
37. Hung PF, Hong TM, Hsu YC, Chen HY, Chang YL, Wu CT, Chang GC, Jou YS, Pan SH and Yang PC. The motor protein KIF14 inhibits tumor growth and cancer metastasis in lung adenocarcinoma. PloS one. 2013; 8(4):e61664.
38. Hsu YC, Chen HY, Yuan S, Yu SL, Lin CH, Wu G, Yang PC and Li KC. Genome-wide analysis of three-way interplay among gene expression, cancer cell invasion and anti-cancer compound sensitivity. BMC medicine. 2013; 11:106.
39. Cheng SP, Liu CL, Hsu YC, Chang YC, Huang SY and Lee JJ. Expression and biologic significance of adiponectin receptors in papillary thyroid carcinoma. Cell biochemistry and biophysics. 2013; 65(2):203-210.
40. Wang JJ, Hung HF, Huang ML, Lee HJ, Chern YT, Chang YF, Chi CW and Hsu YC. Role of p21 as a determinant of 1,6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane response in human HCT-116 colon carcinoma cells. Oncology reports. 2012; 27(2):529-534.
41. Cheng SP, Liu CL, Hsu YC, Chang YC, Huang SY and Lee JJ. Regulation of leptin receptor expression in human papillary thyroid cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2012; 66(6):469-473.
42. Yuan S, Yu SL, Chen HY, Hsu YC, Su KY, Chen HW, Chen CY, Yu CJ, Shih JY, Chang YL, Cheng CL, Hsu CP, Hsia JY, et al. Clustered genomic alterations in chromosome 7p dictate outcomes and targeted treatment responses of lung adenocarcinoma with EGFR-activating mutations. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2011; 29(25):3435-3442.
43. Cheng SP, Yin PH, Hsu YC, Chang YC, Huang SY, Lee JJ and Chi CW. Leptin enhances migration of human papillary thyroid cancer cells through the PI3K/AKT and MEK/ERK signaling pathways. Oncology reports. 2011; 26(5):1265-1271.
44. Hsu YC, Yuan S, Chen HY, Yu SL, Liu CH, Hsu PY, Wu G, Lin CH, Chang GC, Li KC and Yang PC. A four-gene signature from NCI-60 cell line for survival prediction in non-small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009; 15(23):7309-7315.
45. Chang YF, Hsu YC, Hung HF, Lee HJ, Lui WY, Chi CW and Wang JJ. Quercetin induces oxidative stress and potentiates the apoptotic action of 2-methoxyestradiol in human hepatoma cells. Nutrition and cancer. 2009; 61(5):735-745.
46. Hsu YC, Lee HC, Ping YH, Liu TY, Lui WY and Chi CW. Mitochondria are an essential mediator of nitric oxide/cyclic guanosine 3',5'-monophosphate blocking of glucose depletion induced cytotoxicity in human HepG2 cells. Molecular cancer research : MCR. 2007; 5(9):923-932.
會議論文Conference paper
[1] Yi-Chiung Hsu, Hsuan-Yu Chen, Cin-Di Wang, Ker-Chau Li. Integrative genomic analysis of lung cancer cell lines. 2015 The 9th Conference of the Asian Regional Section of the IASC, Singapore. (Invited speaker)
[2] Yi-Chiung Hsu, Hsuan-Yu Chen, Cin-Di Wang, and Ker-Chau Li. Cancer panel sequencing and survival characteristics in breast cancer 2016 Organization for Oncology and Translational Research (OOTR) 12th Annual Conference. Kyoto, Japan.  (Young Scientist Travel Award).
[3] Yi-Chiung Hsu. Genome-wide Analysis of Three-Way Interplay among
Gene Expression, Cancer Cell Invasion and Anti-Cancer Compound Sensitivity in Lung Cancer. 2017 15th Annual Congress of International Drug Discovery Science & Technology. Osaka, Japan. (Invited speaker)
[4] Cin-Di Wang, Yi-Chiung Hsu, and Ker-Chau Li. Integrative Genomic Analysis of Lung Cancer Cell Lines. 2017, 76rd Annual Meeting of the Japanese Cancer Association. Yokohama, Japan.
(poster 3279)
[5] Yu-Hsiang Tsou and Yi-Chiung Hsu. Integrative analysis of multiple genomic data types to predict the survival in lung adenocarcinoma. 2017, 76rd Annual Meeting of the Japanese Cancer Association. Yokohama, Japan. (Young Scientist Travel Award).
[6] Yi-Chiung Hsu, Hsuan-Yu Chen, Ker-Chau Li. Mutation spectrum of recurrent tumors in lung adenocarcinoma. 2017 28th Genome Informatics Workshop. Seoul, Korea.
[7] Tsai-Chi Liu, Chao-Ling Yao, Chi-Chung Wang , Yi-Chiung Hsu. Gene expression profiles of human hematopoietic stem cells with different culture systems. 2018 Taiwan-Japan Joint Conference for Genomics and Proteogenomics & Annual Retreat of Taiwan Genomics and Genetics Society (TGGS). Okinawa, Japan.
[8] Yi-Chao Huang and Po-Chuan Lee and Yi-Chiung Hsu. I Anticancer effect of HGK in Oral Squamous Cell Carcinoma 2019, 78rd Annual Meeting of the Japanese Cancer Association. kyoto, Japan.
[9] Po-Chuan Lee and Yi-Chiung Hsu. Cyclic Stretch Database: A web database and analysis platform for gene expression data on circulation stretching. International Research Forum on Biology and Medical Science (IRFBMS 2019). Kaohsiung, Taiwan.
[10] Yi-Chao Huang and Po-Chuan Lee and Yi-Chiung Hsu. The Treatment of oral cancer cell in vitro by daphne genkwa plant extracts. International Research Forum on Biology and Medical Science (IRFBMS 2019). Kaohsiung, Taiwan.
[11] Po-Chuan Lee and Yi-Chiung Hsu. Exosome-mediated gefitinib resistance in Lung adenocarcinoma PC9/PC9IR cells.台灣基因體暨遺傳學會2019年年終學術研討會. Yunlin, Taiwan.
[12] Yi-Xuan Li and Yi-Chiung Hsu. Role of TP53 Mutations in EGFR-Mutated Patients Treated with Tyrosine Kinase Inhibitors. 台灣基因體暨遺傳學會2019年年終學術研討會. Yunlin, Taiwan.
[13] Po-Chuan Lee and Yi-Chiung Hsu. Cyclic Stretch Database: A web database and analysis platform for gene expression data on circulation stretching. 2020系統生物與生物資訊學術交流研討會Taoyuan, Taiwan. (碩士班第二名)
[14] Yi-Xuan Li and Yi-Chiung Hsu. Role of TP53 Mutations in EGFR-Mutated Patients Treated with Tyrosine Kinase Inhibitors. 2020系統生物與生物資訊學術交流研討會Taoyuan, Taiwan.
[15] Tzu-Yun Chin, Chung-Te Le, Yu Jui Fan, and Yi-Chiung Hsu. The effect of PM2.5 in human heart cell with microfluidic dynamic culture system. 2020國際智慧感測器研討會暨第25屆台灣化學感測器科技研討會/第23屆微奈米系統工程研討會. Kaohsiung, Taiwan.

專利 Patent
1. 發明專利:一種用以評估大腸直腸癌肝轉移病患之預後的方法
專利國家:中華民國專利號碼: I670498專利期間201909~ 201909
2. 發明專利: 訓練類神經網路以預測個體基因表現特徵的方法及系統
專利國家:中華民國專利號碼: I709904專利期間202011~ 203911
技轉 Technology transfer

獲獎 Award
1. 106-108新聘傑出教師獎
2. 2019台灣創新技術博覽會 (金牌獎)
3. 科技部工程司109年度產學合作計畫成果發表口頭組優良獎
Last Updated: 2022-07-07