welcome to Department of Biomedical Sciences & Engineering.

Faculties in Biomedical Engineering (Biomaterials and Nanomedicine)

Distinguished Professor Yu Hsiang Lee

Posted on: 2021-06-08
Expertise:Biomaterials, Nanomedicine, Drug Delivery, Perfluoro Drug Nanocarriers, Bioreactor, Mechanotransductional Biology

TEL:(03) 4227151 Ext# 27755



Ph.D. : Dept. Chemical Engineering, University of Southern California (CA, USA)

Work Experiences​

2020 - 2023 :  Associate Dean of CHST
2019 -          :  Professor (2022- Distinguished Professor)
2014-  2019 :  Associate Professor
2010 - 2014 :  Assistant Professor
2008 - 2010 :  Postdoctoral Fellow, UCLA Dental Research Institute (CA, USA)
2006 - 2008 :  Research Scientist, Sierra Sciences LLC (NV, USA)

Research Project Feilds

[1] Biomaterials
[2] Nanomedicine
[3] Drug Delivery/Controlled Release
[3] Photo/Chemo/Probiotic/Immune Combinational Therapeutics

Selected Journal paper in 5 years (*Corresponding author):
[1]Lee Y-H*, Lin C-T. Injectable Alginate Complex Hydrogel Loaded with Dual Drug Nanovectors Offers Effective Photochemotherapy Against Triple-Negative Breast Cancer. Biomacromolecules (SCIE). Accepted @ 2/13/2024
[2]Huang C-J, Hsu S-J, Hsu Y-C, Chen L-K, Li C, Huang H-C*, 
Lee Y-H*. Synthesis, Characterization, and Biological Verification of Asialoglycoprotein Receptor-Targeted Lipopolysaccharides-Encapsulated PLGA Nanoparticles for Establishment of Liver Fibrosis Animal Model. Biomaterials Science. 2023; 11: 6650. (SCIE)
[3] Ganzorig B, Zayabaatar E, Pham MT, Shimbolon S, Huang CM, Lee Y-H*Lactobacillus plantarum Generate Electricity Through Flavin Mononucleotide-Mediated Extracellular Electron Transfer to Upregulate Epithelial Type I Collagen Expression and thereby Promote Microbial Adhesion to Intestine. Biomedicines. 2023; 11: 677. (SCIE)
[4] Lee Y-H*, Pham U.N.T. Engineered Indocyanine Green and PD-L1 Inhibitors Co-Loaded Perfluorochemical Double-Layered Nanodroplets Offer Effective Photoimmunotherapy against Colorectal Cancer. Chemical Engineering Journal. 2023; 460: 141819. (SCIE).
[5] Huang C-J, Zayabaatar E, Wang S-M, Keshari S, Peng W-H, Kung H-N, Lee Y-H*Bacillus amyloliquefaciens-inoculated GABA-rich rice upregulate neuropeptide Y to relieve psychological stress through mediations of GABAB receptor and vagus nerves. Biology Bulletin Russ Acad Sci. 2023; 50: 186-193. (SCIE)
[6]. Lin Yu-Jung, Chang Chien B-Y, Lee Y-H*. Injectable and Thermoresponsive Hybrid Hydrogel with Antibacterial, Anti-inflammatory, Oxygen Transport, and Enhanced Cell Growth Activities for Improved Diabetic Wound Healing. European Polymer Journal. 2022; 175: 111364. (SCIE)
[7]. Lee Y-H*, Lin S-J. Chitosan/PVA Hetero-Composite Hydrogel Containing Antimicrobials, Perfluorocarbon Nanoemulsions, and Growth Factor-Loaded Nanoparticles as a Multifunctional Dressing for Diabetic Wound Healing: Synthesis, Characterization, and in vitro/in vivo Evaluation. Pharmaceutics 2022; 14: 537 (SCIE)
[8]. Lee Y-H*, Kuo P-W, Chen C-J, Sue C-J, Hsu Y-F, Pan M-C*. Indocyanine Green-Camptothecin Co-loaded Perfluorocarbon Double-Layer Nanocomposite: A Versatile Nanotheranostics for Photochemotherapy and FDOT Diagnosis of Breast Cancer. Pharmaceutics 2021; 13(9): 1499. (SCIE)
[9]. Lee Y-H*, Chiu C-C, Chang C-Y. Engineered Photo-Chemical Therapeutic Nanocomposites Provide Effective Antibiofilm and Microbicidal Activities against Bacterial Infection in Porous Devices. Biomaterials Science 2021; 9: 1739-1753. (SCIE)
[10]. Lee Y-H*, Hong Y-L, Wu T-L. Development of Chitosan-Based Composite Hydrogel Containing Silver Ions and Growth Factor-Loaded Nanoparticles with Improved Cell Proliferation and Sustainable Antimicrobial Property for Diabetic Wound Healing. Materials Science & Engineering C: Materials for Biological Applications 2021; 118: 111385. (SCIE)
[11]. Hsiao K-H, Huang C-M*, Lee Y-H*. Novel Rifampicin and Indocyanine Green Co-Loaded Perfluorocarbon Nanodroplets Provide Effective in vivo Photo-Chemo-Probiotic Antimicrobility against Pathogen of Acne Vulgaris Cutibacterium acnes. Nanomaterials 2020; 10(6): 1095. (SCIE)
[12]. Lee Y-H*, Sun J-H. Multifunctional Fluorocarbon Photobioreactor System: A Novel Integrated Device for CO2 Segregation, O2 Collection, and Enhancement of Microalgae Growth and Bioproductions. Bioprocess and Biosystems Engineering 2019; 42: 1591-1601. (SCIE)
[13]. Lee Y-H*, Tuyet P-T. Synthesis and Biological Evaluation of Quercetin-Zinc (II) Complex for Anticancer and Anti-Metastasis of Human Bladder Cancer Cells. In Vitro Cellular & Developmental Biology - Animal 2019; 55(6): 395-404. (SCIE)
[14]. Hsiao K-H, Huang C-M*, Lee Y-H*. Development of Rifampicin-Indocyanine Green-Loaded Perfluorocarbon Nanodroplets for Photo-Chemo-Probiotic Antimicrobial Therapy. Frontiers in Pharmacology 2018; 9: 1254.(SCIE)
[15]. Lee Y-H*, Lin Y-C. Anti-EGFR Indocyanine Green-Mitomycin C-loaded Perfluorocarbon Double Nanoemulsion: A Novel Nanostructure for Targeted Photochemotherapy of Bladder Cancer Cells. Nanomaterials 2018; 8: 283. (SCIE)
[16]. Lee Y-H*, Lai C-W, Cheng Y-C*. Fluid Shear Stress Induces Cell Cycle Arrest in Human Urinary Bladder Transitional Cell Carcinoma through Bone Morphogenetic Protein Receptor-Smad1/5 Pathway. Cellular and Molecular Bioengineering 2018; 11: 185-195. (SCIE)
[17]. Lee Y-H*, Weng T-C. Development of Synthetic Perfluorinated Photobioreactor System for Simultaneous Carbon Dioxide Separation and Promotion of Microalgae Growth and Productions. Journal of Chemical Technology and Biotechnology 2018; 93: 1065-1074. (SCIE)
[18]. Lee Y-H*, Yeh C-H. Laminar Shear Stress Inhibits High Glucose-Induced Migration and Invasion in Human Bladder Cancer Cells. In Vitro Cellular & Developmental Biology - Animal 2018; 54: 120-128. (SCIE)
[19]. Lee Y-H*, Ma Y-T. Synthesis, Characterization, and Biological Verification of Anti-HER2 Indocyanine Green-Doxorubicin-Loaded Polyethyleneimine-Coated Perfluorocarbon Double Nanoemulsions for Targeted Photochemotherapy of Breast Cancer Cells. Journal of Nanobiotechnology 2017; 15(1): 41 (SCIE)
[20]. Lee Y-H*, Chang D-S. Fabrication, Characterization, and Biological Evaluation of Anti-HER2 Indocyanine Green-Doxorubicin-Encapsulated PEG-b-PLGA Copolymeric Nanoparticles for Targeted Photochemotherapy of Breast Cancer Cells. Scientific Reports 2017; 7: 46688 (SCIE)
[21]. Lee Y-H*, Li P-H. Using Resonant Ultrasound Field-Incorporated Dynamic Photobioreactor System to Enhance Medium Replacement Process for Concentrated Microalgae Cultivation in Continuous Mode. Chemical Engineering Research and Design 2017; 118(2017): 112-120 (SCIE).


[1] 李宇翔,葉昱伶。培養擬球藻之系統。中華民國專利 發明第I 487481號。(2015-2033)
[2] 李宇翔,馬韻婷。藥物丸粒、其醫藥組合物及其用途。中華民國專利 發明第I 684464號。(2020-2036)
[3] 李宇翔,張簡博穎、林聖喆。凝膠、其製備方法及其用途。中華民國專利 發明第I 805230號。(2023-2042)

Last Updated: 2024-02-16