發布日期： 2024-05-16
專長：生醫材料、奈米醫學、藥物輸送、控制釋放、全氟碳藥物載體、生物反應器、流體傳導生物力學
連絡電話：(03) 4227151轉27755
E-mail：yuhsianl@ncu.edu.tw
Education
Ph.D. : Dept. Chemical Engineering, University of Southern California (CA, USA)
Work Experiences
2025 - : NCU Secretary General
2020 - 2023 : Associate Dean of CHST
2019 - : Professor (2022- Distinguished Professor)
2014- 2019 : Associate Professor
2010 - 2014 : Assistant Professor
2008 - 2010 : Postdoctoral Fellow, UCLA Dental Research Institute (CA, USA)
2006 - 2008 : Research Scientist, Sierra Sciences LLC (NV, USA)
Research Project Feilds
[1] Biomaterials
[2] Nanomedicine
[3] Drug Delivery/Controlled Release
[3] Photo/Chemo/Probiotic/Immune Combinational Therapeutics
Selected Journal paper in 5 years (*Corresponding author):
[1] Yadlapalli BK, Huang T-C, Lee Y-H, Cheng Y-C, Chen W-Y. Deferoxamine-B–Functionalized Silicon Nanowire Field-Effect Transistor Interfaces for Ultralow-Concentration Fe3+ Detection in Semiconductor Process Chemicals. ACS Applied Materials & Interfaces 2026; 18(30): 41903-41916. (SCIE).
[2] Wang T-J, Chen C-A, Lee Y-H* Development of Antiseptic and Epidermal Growth Factor Co-Loaded Thermoresponsive Composite Hydrogel for Joint Treatment of Deep Wounds. Gels. 2026; 12: 539. (SCIE).
[3] Chyuan IT, Chiu M-H, Lai C-Y, Tsao C-W, Cheng Y-C, Lee Y-H, Hu W-W. Composition-Tunable Hyaluronic Acid/Zwitterionic Hybrid Fibrous Biointerfaces for Programmable CD44-Mediated Cell Adhesion and Flow-Triggered Release. Colloids and Surfaces B: Biointerfaces 2026; 265: 115676. (SCIE).
[4]Nguyen OTK, Chen P-T, Lai C-S, Lee Y-H, Nargotra P, Liu Y-C*, Kuo C H*. Green Synthesis of Gallic Acid-Chitosan Oligosaccharide Conjugates and their Incorporation into Bacterial Cellulose for Enhanced Antioxidant and Tyrosinase Inhibition Activities. International Journal of Biological Macromolecules. 2026; 359: 151775. (SCIE).
[5] Yadlapalli BK, Wu P-J, Lee Y-H, Chen W-Y. Simultaneous detection of miR-21 and miR-155 using a multiplexed silicon nanowire FET biosensor. Microchemical Journal. 2026; 224: 117657. (SCIE).
[6] Hsu S-J, Hsu Y-C, Yen P-L, Lung C-F, Li C, Huang H-C*, Lee Y-H*. Asialoglycoprotein Receptor-Bound PLGA Nanoparticles Loaded with Riociguat Targetedly Ameliorate Portal Hypertension in Liver Cirrhosis. International Journal of Biological Macromolecules 2026; 360: 151957. (SCIE).
[7] Lee Y-H*, Chung C-L. Development of Thermoresponsive Composite Hydrogel Loaded with Indocyanine Green and Camptothecin for Photochemotherapy of Skin Cancer After Surgery. Gels 2025; 11(1): 71. (SCIE).
[8] Lee Y-H*, Huang C-Y. Engineered Perfluorochemical Cancer-Derived Exosomes Loaded with Indocyanine Green and Camptothecin Provide Targeted Photochemotherapy for Effective Cancer Treatment. International Journal of Nanomedicine 2025; 20: 327-342. (SCIE)
[9] Lee Y-H*, Chen C-S. Carcinomembrane-Camouflaged Perfluorochemical Dual-Layer Nanopolymersomes Bearing Indocyanine Green and Camptothecin Effectuate Targeting Photochemotherapy of Cancer. ACS Biomaterials Science & Engineering. 2024; 10(10): 6332-6343. (SCIE)
[10] Lee Y-H*, Lin C-T. Injectable Alginate Complex Hydrogel Loaded with Dual Drug Nanovectors Offers Effective Photochemotherapy Against Triple-Negative Breast Cancer. Biomacromolecules 2024; 25: 2041-2051. (SCIE).
[11] Huang C-J, Hsu S-J, Hsu Y-C, Chen L-K, Li C, Huang H-C*, Lee Y-H*. Synthesis, Characterization, and Biological Verification of Asialoglycoprotein Receptor-Targeted Lipopolysaccharides-Encapsulated PLGA Nanoparticles for Establishment of Liver Fibrosis Animal Model. Biomaterials Science. 2023; 11: 6650. (SCIE)
[12] Ganzorig B, Zayabaatar E, Pham MT, Shimbolon S, Huang CM, Lee Y-H*. Lactobacillus plantarum Generate Electricity Through Flavin Mononucleotide-Mediated Extracellular Electron Transfer to Upregulate Epithelial Type I Collagen Expression and thereby Promote Microbial Adhesion to Intestine. Biomedicines. 2023; 11: 677. (SCIE)
[13] Lee Y-H*, Pham U.N.T. Engineered Indocyanine Green and PD-L1 Inhibitors Co-Loaded Perfluorochemical Double-Layered Nanodroplets Offer Effective Photoimmunotherapy against Colorectal Cancer. Chemical Engineering Journal. 2023; 460: 141819. (SCIE).
[14] Huang C-J, Zayabaatar E, Wang S-M, Keshari S, Peng W-H, Kung H-N, Lee Y-H*. Bacillus amyloliquefaciens-inoculated GABA-rich rice upregulate neuropeptide Y to relieve psychological stress through mediations of GABAB receptor and vagus nerves. Biology Bulletin Russ Acad Sci. 2023; 50: 186-193. (SCIE)
[15] Lin Yu-Jung, Chang Chien B-Y, Lee Y-H*. Injectable and Thermoresponsive Hybrid Hydrogel with Antibacterial, Anti-inflammatory, Oxygen Transport, and Enhanced Cell Growth Activities for Improved Diabetic Wound Healing. European Polymer Journal. 2022; 175: 111364. (SCIE)
[2] Wang T-J, Chen C-A, Lee Y-H* Development of Antiseptic and Epidermal Growth Factor Co-Loaded Thermoresponsive Composite Hydrogel for Joint Treatment of Deep Wounds. Gels. 2026; 12: 539. (SCIE).
[3] Chyuan IT, Chiu M-H, Lai C-Y, Tsao C-W, Cheng Y-C, Lee Y-H, Hu W-W. Composition-Tunable Hyaluronic Acid/Zwitterionic Hybrid Fibrous Biointerfaces for Programmable CD44-Mediated Cell Adhesion and Flow-Triggered Release. Colloids and Surfaces B: Biointerfaces 2026; 265: 115676. (SCIE).
[4]Nguyen OTK, Chen P-T, Lai C-S, Lee Y-H, Nargotra P, Liu Y-C*, Kuo C H*. Green Synthesis of Gallic Acid-Chitosan Oligosaccharide Conjugates and their Incorporation into Bacterial Cellulose for Enhanced Antioxidant and Tyrosinase Inhibition Activities. International Journal of Biological Macromolecules. 2026; 359: 151775. (SCIE).
[5] Yadlapalli BK, Wu P-J, Lee Y-H, Chen W-Y. Simultaneous detection of miR-21 and miR-155 using a multiplexed silicon nanowire FET biosensor. Microchemical Journal. 2026; 224: 117657. (SCIE).
[6] Hsu S-J, Hsu Y-C, Yen P-L, Lung C-F, Li C, Huang H-C*, Lee Y-H*. Asialoglycoprotein Receptor-Bound PLGA Nanoparticles Loaded with Riociguat Targetedly Ameliorate Portal Hypertension in Liver Cirrhosis. International Journal of Biological Macromolecules 2026; 360: 151957. (SCIE).
[7] Lee Y-H*, Chung C-L. Development of Thermoresponsive Composite Hydrogel Loaded with Indocyanine Green and Camptothecin for Photochemotherapy of Skin Cancer After Surgery. Gels 2025; 11(1): 71. (SCIE).
[8] Lee Y-H*, Huang C-Y. Engineered Perfluorochemical Cancer-Derived Exosomes Loaded with Indocyanine Green and Camptothecin Provide Targeted Photochemotherapy for Effective Cancer Treatment. International Journal of Nanomedicine 2025; 20: 327-342. (SCIE)
[9] Lee Y-H*, Chen C-S. Carcinomembrane-Camouflaged Perfluorochemical Dual-Layer Nanopolymersomes Bearing Indocyanine Green and Camptothecin Effectuate Targeting Photochemotherapy of Cancer. ACS Biomaterials Science & Engineering. 2024; 10(10): 6332-6343. (SCIE)
[10] Lee Y-H*, Lin C-T. Injectable Alginate Complex Hydrogel Loaded with Dual Drug Nanovectors Offers Effective Photochemotherapy Against Triple-Negative Breast Cancer. Biomacromolecules 2024; 25: 2041-2051. (SCIE).
[11] Huang C-J, Hsu S-J, Hsu Y-C, Chen L-K, Li C, Huang H-C*, Lee Y-H*. Synthesis, Characterization, and Biological Verification of Asialoglycoprotein Receptor-Targeted Lipopolysaccharides-Encapsulated PLGA Nanoparticles for Establishment of Liver Fibrosis Animal Model. Biomaterials Science. 2023; 11: 6650. (SCIE)
[12] Ganzorig B, Zayabaatar E, Pham MT, Shimbolon S, Huang CM, Lee Y-H*. Lactobacillus plantarum Generate Electricity Through Flavin Mononucleotide-Mediated Extracellular Electron Transfer to Upregulate Epithelial Type I Collagen Expression and thereby Promote Microbial Adhesion to Intestine. Biomedicines. 2023; 11: 677. (SCIE)
[13] Lee Y-H*, Pham U.N.T. Engineered Indocyanine Green and PD-L1 Inhibitors Co-Loaded Perfluorochemical Double-Layered Nanodroplets Offer Effective Photoimmunotherapy against Colorectal Cancer. Chemical Engineering Journal. 2023; 460: 141819. (SCIE).
[14] Huang C-J, Zayabaatar E, Wang S-M, Keshari S, Peng W-H, Kung H-N, Lee Y-H*. Bacillus amyloliquefaciens-inoculated GABA-rich rice upregulate neuropeptide Y to relieve psychological stress through mediations of GABAB receptor and vagus nerves. Biology Bulletin Russ Acad Sci. 2023; 50: 186-193. (SCIE)
[15] Lin Yu-Jung, Chang Chien B-Y, Lee Y-H*. Injectable and Thermoresponsive Hybrid Hydrogel with Antibacterial, Anti-inflammatory, Oxygen Transport, and Enhanced Cell Growth Activities for Improved Diabetic Wound Healing. European Polymer Journal. 2022; 175: 111364. (SCIE)
[16] Lee Y-H*, Lin S-J. Chitosan/PVA Hetero-Composite Hydrogel Containing Antimicrobials, Perfluorocarbon Nanoemulsions, and Growth Factor-Loaded Nanoparticles as a Multifunctional Dressing for Diabetic Wound Healing: Synthesis, Characterization, and in vitro/in vivo Evaluation. Pharmaceutics 2022; 14: 537 (SCIE)
[17] Lee Y-H*, Kuo P-W, Chen C-J, Sue C-J, Hsu Y-F, Pan M-C*. Indocyanine Green-Camptothecin Co-loaded Perfluorocarbon Double-Layer Nanocomposite: A Versatile Nanotheranostics for Photochemotherapy and FDOT Diagnosis of Breast Cancer. Pharmaceutics 2021; 13(9): 1499. (SCIE)
[18] Lee Y-H*, Chiu C-C, Chang C-Y. Engineered Photo-Chemical Therapeutic Nanocomposites Provide Effective Antibiofilm and Microbicidal Activities against Bacterial Infection in Porous Devices. Biomaterials Science 2021; 9: 1739-1753. (SCIE)
[19] Lee Y-H*, Hong Y-L, Wu T-L. Development of Chitosan-Based Composite Hydrogel Containing Silver Ions and Growth Factor-Loaded Nanoparticles with Improved Cell Proliferation and Sustainable Antimicrobial Property for Diabetic Wound Healing. Materials Science & Engineering C: Materials for Biological Applications 2021; 118: 111385. (SCIE)
[20] Hsiao K-H, Huang C-M*, Lee Y-H*. Novel Rifampicin and Indocyanine Green Co-Loaded Perfluorocarbon Nanodroplets Provide Effective in vivo Photo-Chemo-Probiotic Antimicrobility against Pathogen of Acne Vulgaris Cutibacterium acnes. Nanomaterials 2020; 10(6): 1095. (SCIE)
專利
[1] 李宇翔，葉昱伶。培養擬球藻之系統。中華民國專利 發明第I 487481號。(2015-2033)
[2] 李宇翔，馬韻婷。藥物丸粒、其醫藥組合物及其用途。中華民國專利 發明第I 684464號。(2020-2036)
[3] 李宇翔，張簡博穎、林聖喆。凝膠、其製備方法及其用途。中華民國專利 發明第I 805230號。(2023-2042)
更新日期: 2026-09-07