劉淑貞副教授
發布日期： 2024-05-16
研究主題 (Research Subjects):
- Tumor microenvironment (腫瘤微環境)
- Molecular mechanisms of HNSCC progression (頭頸癌惡性化機轉)
- Tumor single cell transcriptomics (癌組織單細胞轉錄體研究)
- Immuno-Oncology (腫瘤免疫)
- Epstein-Barr virus-associated carcinogenesis (EB病毒相關惡性腫瘤)
- Radiation oncology/ Cancer radioresistance (癌症放射治療抗性機轉)
連絡電話：03-4227151#27768
E-mail：jennyliu66@gmail.com
Education (學歷):
2009 Ph.D. Institute of Life Science (Academia Sinica/National Defense Medical Center/National Health Research Institutes, Taiwan)
2000 M.S Radiological Sciences, National Yang-Ming University, Taiwan
學會 (Professional Memeberships):
Taiwan Society for Therapeutic Radiology and Oncology (台灣放射腫瘤學會)
The Taiwan Oncology Society (中華民國癌症醫學會)
- Tumor microenvironment (腫瘤微環境)
- Molecular mechanisms of HNSCC progression (頭頸癌惡性化機轉)
- Tumor single cell transcriptomics (癌組織單細胞轉錄體研究)
- Immuno-Oncology (腫瘤免疫)
- Epstein-Barr virus-associated carcinogenesis (EB病毒相關惡性腫瘤)
- Radiation oncology/ Cancer radioresistance (癌症放射治療抗性機轉)
連絡電話：03-4227151#27768
E-mail：jennyliu66@gmail.com
Education (學歷):
2009 Ph.D. Institute of Life Science (Academia Sinica/National Defense Medical Center/National Health Research Institutes, Taiwan)
2000 M.S Radiological Sciences, National Yang-Ming University, Taiwan
學會 (Professional Memeberships):
Taiwan Society for Therapeutic Radiology and Oncology (台灣放射腫瘤學會)
The Taiwan Oncology Society (中華民國癌症醫學會)
主要研究計畫(Grants)
1. 探討 STING-ATM訊息路徑在鼻咽癌放射治療所誘導之免疫調節與腫瘤微環境的重塑作用 (國科會，2026/08/01~2027/07/31，主持人) 。
2. 探索以LIF及LIFR為標靶的頭頸腫瘤免疫輔助治療潛能與抑制劑開發 (國科會，2023/08/01~2026/07/31，主持人) 。
3. 白血病抑制因子於口腔鱗狀上皮細胞癌的免疫調控機制(109-2314-B-008-001-MY3) (科技部, 2020/08/01~2023/07/31; 主持人) 。
4. 含EBV病毒產物之外吐小體對鼻咽癌細胞及微環境基質細胞的調控-II (科技部 108-2314-B-008-003-)(主持人)。
5. 榮台聯大整合型研究計畫 (VGHUST108-G4-3-1, 2019/1/1~2019/12/31, 主持人) 。
6. 含EBV病毒產物之外吐小體對鼻咽癌細胞及微環境基質細胞的調控 (科技部 107-2314-B-008-003-)(主持人)。
7. 榮台聯大整合型研究計畫(VGHUST107-G4-2-1, 2018/1/1~2018/12/31, 主持人) 。
8. 科技部延攬研究學者計畫(2015/08/01~2018/07/31): EBV病毒調控脂肪細胞分化並重建腫瘤微環境 (MOST -104-2321-B-008-003-MY3)(主持人)。
9. 國際科技人士短期訪問計畫(計畫編號：106WCSFA0700029)(國立中央大學生醫科學與工程學系主辦「2017 生物醫學工程科技研討會」暨「科技部醫學工程學門成果發表會」。
10. 榮台聯大整合型研究計畫(VGHUST106-G4-2-1, 2017/1/1~2017/12/31, 主持人) 。
專利與技術報告 (Patents & technical reports)
1. Potentiation of nasopharyngeal cancer radiotherapy by inhibitors of leukemia inhibitory factor (美國)( US9,194,872 B2; 專利期限2015/11 至2034/04)。
2. 評估癌症於治療後情況的方法及其相關應用 (中國)( CN 104623663 A; 專利期限2017 /7/14至2034/1/26)
3. 鼻咽癌治療的醫藥 (台灣，發明第I486172，專利期間: 2015/06~2033/11)。
主要著作 (Selected Publications)
-Tzu-Tung Liu, Kai-Ping Chang, Meng-Hsin Li, Yun-Hua Sui, Fang-Yu Tsai, Hsuan-Chung Chen, Chen-Han Huang, Ya-Wen Chen, Shih Sheng Jiang*, Shu-Chen Liu*. Extracellular vesicle-associated LMP1 from EBV-positive nasopharyngeal carcinoma induces LIF-mediated immunosuppressive macrophage polarization and impairs anti-tumor immunity, Cancer Letters, 661, 2026. (IF:11.8)
-Wei-Chen Yen #, Shu-Chen Liu #, Shih-Sheng Jiang, Chia-Yu Yang, Fang-Yu Tsai, Tzu‑Tung Liu, Yun‑Hua Sui, Meng-Hsin Li, Hsing-Wen Cheng, Jui-Shan Yi , Chi-Yin Lee, Wan-Ling Wang, Tsung-You Tsai, Yenlin Huang, Kai-Ping Chang *. RANBP1 promotes oral cancer progression through activating YAP1 and NDUFB3 derived from the database of single-cell sequencing. Cancer Cell Int. 2026 Jun 10;26(1):284. doi: 10.1186/s12935-026-04361-9. PMID: 42271351; PMCID: PMC13480108. (#co-first author). (IF:7.0)
-Yun-Xuan Zhang, Shu-Chen Liu, and Lin I (2026, Jun). Collective dynamics of natural killer cells interacting with cancer and fibroblast cells (Featured article). PHYSICAL REVIEW E, 113, L062401 (2026). (IF: 2.5)
-Sanskruti Swain, I-Hsuan Chou, Bikash C. Mallick, Shu-Chen Liu, Gin-Shin Chen, Hsing-Ying Lin, Chen-Han Huang (2026, Feb). Bimetallic Au–Ag Nanoclusters as a Photo-Responsive Oxidase-Like Nanozyme for Antioxidant Detection and Intracellular Redox Analysis. Small Science, 2026, 6, e202500560. (IF:7.0)
-Ssu-Han Wang, Yu-Lin Chen, Shih-Han Huang, Yu-Ke Fu, Su-Fang Lin, Shih Sheng Jiang, Shu-Chen Liu, Jenn-Ren Hsiao, Jang-Yang Chang, Ya-Wen Chen. Tumor cell-derived ISG15 promotes fibroblast recruitment in oral squamous cell carcinoma via CD11a-dependent glycolytic reprogramming. Oncogenesis. 2025 Mar 11;14(1):6. doi: 10.1038/s41389-025-00549-2. PMID: 40069143; PMCID: PMC11897235. (IF: 6.0)
-Sanskruti Swain, Ting-Yi Lin, I-Hsuan Chou, Shu-Chen Liu, Bikash C. Mallick, Hsing-Ying Lin, Chen-Han Huang. Photoactive nanocatalysts as DTT-assisted BSA-AuNCs with enhanced oxidase-mimicking ability for sensitive fluorometric detection of antioxidants. Journal of Nanobiotechnology 22, 585 (2024) (IF: 15.0).
-Yumiko Yamada, Yu-Chih Wang, Hao-Ping Liu, Greg Ryan Gerongano, Ching-Yu Tseng, Shu-Chen Liu, Guan-Ru Liao, Chao-Chin Chang, Jiunn-Wang Liao, Mei-Lin Wang, Yuan-Yen Chang, Fong-Yuan Lin, Wei-Li Hsu. Development of attenuated Orf virus as a safe oncolytic viral vector for nasopharyngeal carcinoma treatment. Virol J. 2025 Feb 25;22(1):50. doi: 10.1186/s12985-025-02672-3. PMID: 40001231; PMCID: PMC11863438. (IF: 4.1)
-Shu-Chen Liu*, Chun-I Wang, Tzu-Tung Liu, Ngan-Ming Tsang, Yun-Hua Sui, Jyh-Lyh Juang*. A 3-gene signature comprising CDH4, STAT4 and EBV-encoded LMP1 for early diagnosis and predicting disease progression of nasopharyngeal carcinoma. Discover Oncology. (2023) 14:119. (IF: 2.8)
-Po-Ju Lee, Yun-Hua Sui, Tzu-Tung Liu, Ngan-Ming Tsang, Chen-Han Huang, Ting-Yi Lin, Kai-Ping Chang*, Shu-Chen Liu*. Epstein-Barr viral product-containing exosomes promote fibrosis and nasopharyngeal carcinoma progression through activation of YAP1/FAPα signaling in fibroblasts. Journal of Experimental & Clinical Cancer Research 2022 Aug 20;41(1):254. doi: 10.1186/s13046-022-02456-5. PMID: 35986369. (IF: 14.3) (corresponding author).
-Shu-Chen Liu*, Ngan-Ming Tsang, Po-Ju Lee, Yun-Hua Sui, Chen-Han Huang and Tzu-Tung Liu. Epstein-Barr virus induces adipocyte dedifferentiation to modulate the tumor microenvironment. Cancer Research. 2021 Jun 15;81(12):3283-3294. (IF: 22.6) (the first & corresponding author)
-Ting-Wen Chen, Kai-Ping Chang, Chun-Chia Cheng, Cheng-Yi Chen, Shu-Wen Hong, Zong-Lin Sie, Hsing-Wen Cheng, Wei-Chen Yen, Yenlin Huang, Shu-Chen Liu*, and Chun-I Wang*. Characterization of Recurrent Relevant Genes Reveals a Novel Role of RPL36A in Radioresistant Oral Squamous Cell Carcinoma. Cancers 2021, 13(22), 5623. (IF: 4.8) (corresponding author).
-Shu-Chen Liu*, Tien Hsu , Yu-Sun Chang, An-Ko Chung, Shih Sheng Jiang, Chun-Nan OuYang, Chiou-Hwa Yuh, Chuen Hsueh, Ya-Ping Liu, Ngan-Ming Tsang*. Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling. Nature communications, (2018) 9: 5105. (IF: 18.1) (the first & corresponding author)
-Hsiang-Ying Chen, Yi-Teng Hsiao, Shu-Chen Liu , Tien Hsu, Wei-Yen Woon, Lin I *. Enhancing Cancer Cell Collective Motion and Speeding up Confluent Endothelial Dynamics through Cancer Cell Invasion and Aggregation. Physical Review Letters. 2018, 121(1): 01810. (IF: 9.4).
-Tzong-Shoon Wu1, Lian-Chen Wang1, Shu-Chen Liu1, Ting-Yu Hsu, Chun-Yen Lin, Gou-Jin Feng, Jian-Ming Chen, Hao-Ping Liu, I-Che Chung, Tzu-Chen Yen, Yu-Sun Chang, Shuen-Kuei Liao, Chen Chang, Kai-Ping N Chow*. EBV oncogene N-LMP1 induces CD4 T cell-mediated angiogenic blockade in the murine tumor model. J Immunol. 2015 May 1;194(9):4577-87 (1co-first author) (highlight article, IF: 4.2).
-Shu-Chen Liu and Yu-Sun Chang. Role of leukemia inhibitory factor in nasopharyngeal carcinogenesis. Molecular & Cellular Oncology. 2014 Jul 15 1(1): e29900. (IF: 2.5).
-Shu-Chen Liu, Ngan-Ming Tsang, Wen-Che Chiang, Kai-Ping Chang, Chuen Hsueh, Ying Liang, Jyh-Lyh Juang, Kai-Ping N Chow, Yu-Sun Chang*Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance. J Clin Invest. 2013 Dec 2;123(12):5269-83 (IF:14.3, highlight article) (first author).
-Hao-Ping Liu, Chia-Chun Chen, Chih-Ching Wu, Yi-Chuan Huang, Shu-Chen Liu, Ying Liang, Kai-Ping Chang, Yu-Sun Chang. Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells. PLoS Pathog. 2012 May;8(5): e1002690 (IF: 4.9)
-Shu-Chen Liu, Yee-Min Jen, Shih Sheng Jiang, Junn-Liang Chang, Chao A Hsiung, Chih-Hung Wang, Jyh-Lyh Juang. G(alpha)12-mediated pathway promotes invasiveness of nasopharyngeal carcinoma by modulating actin cytoskeleton reorganization. Cancer Research. 2009 Aug 1;69(15):6122-30 (IF: 12.7) (first author)
-Chi-Chung Wen, Shu-Chen Liu, Li-Chu Chien, Chung-Yen Lin, Chao A Hsiung, Jyh-Lyh Juang. Temporal transcription program of recombinant Autographa californica multiple nucleopolyhedrosis virus. J Virol. 2006 Sep; 80(18):8989-99.
更新日期: 2026-10-21