陳靖昀助理教授
發布日期： 2024-05-16
專長：組織工程、再生醫學、生物反應器、非動物替代平台開發、藥篩平台開發
連絡電話：03-4227151轉27765
E-mail：chingyun523@gmail.com
Education
1.Ph.D.: 2008/09-2017/06, Department of Biomedical Engineering, National Taiwan University (NTU), Taiwan
2. Master: 2006/09-2008/06, Department of Biomedical Engineering, Chung Yuan Christian University (CYCU), Taiwan
3. Bachelor: 2002/09-2006/06, Department of Biological Technology, China Medical University (CMU), Taiwan
Experiences
1.2020/08- , Assistant Professor, Department of Biomedical Sciences & Engineering, National Central University, Taiwan
2.2017/08-2020/07, Postdoc Fellow, Institute of Biomedical Engineering & Nanomedicine, National Health Research Institutes (NHRI), Taiwan
3.2019/08-2020/01, Adjunct Assistant Professor, Graduate Program of Biotechnology and Pharmaceutical Industries, National Taiwan Normal University, Taiwan
4.2015/09-2017/07, Research Assistant, Institute of Biomedical Engineering & Nanomedicine, National Health Research Institutes (NHRI), Taiwan
5.2008/09-2015/08, Adjunct Research Assistant, Department of Orthopedics, National Taiwan University Hospital (NTUH), Taiwan
6.2006/09-2008/06, Teaching Assistant, Department of Biomedical Engineering, Chung Yuan Christian University (CYCU), Taiwan
Major
1.Regenerative Medicine
2.Tissue Engineering
3.Stem Cells
4.Biomaterials
Professional Activity
i.International Academic Connections
1.Invited speech, “Forming Chondral-like Tissues in 3D Tri-copolymer Scaffolds and Cultured in the Self-designed Bioreactor,” EORS-2020, 2020 Sep., Turkey (On-line Conference).
2.Invited speech, “Enhancing Aging Bone Morrow MSCs Toward Osteogenesis via IGF-1 Overexpression for Bone Regeneration,” EWAB-2019, 2019 Sep., Indonesia.
3.Invited speech, “Using Continuous Bioreactor System to Cultivate Human Bone-like Tissues for Bone Tissue Engineering,” YUCOMAT 2018 Sep., Montenegro.
4.Invited speech, "Forming Human Bone-like Tissues in Continuous Bioreactor System for Bone Tissue Engineering," 5th Warsaw International Healthcare Exhibition, 2017 Oct., Poland.
Domestic Academic Connections
1.Invited speech, “Applications of In-vitro Three-dimensional Dynamic Bioreactor System in Cell Therapy,” 2022 May, Tainan (NCKU).
2.Invited speech, “Applications of In-vitro Three-dimensional Dynamic Culture System in Regenerative Medicine,” 2022 May, New Taipei (MMC).
3.Invited speech, “In-vitro Biomimetic Tissue Engineering Applied on Regenerative Medicine,” 2022 Apr., Taipei (NTU).
4.Invited speech, “Commercial applications of In-vitro Biomimetic Cell Culture System in Biomedical Field,” 2022 Mar., Taichung (CMU).
5.Invited speech, “In-vitro Biomimetic Tissue Engineering for Regenerative Medicine,” 2022 Feb., Taoyuan (CYCU).
6.Invited speech, “Talking about the Application of the In-vitro Biomimetic Bioreactor System in the Biomedical Industry,” 2021 Nov., Taoyuan (NCU).
7.Invited speech, “The Dynamic 3D Bioreactor System Applied on Biomimetic Organoid Formation,” 2021 Oct., Taoyuan (CYCU).
8.Invited speech, “The Self-designed Dynamic 3D Cell Culture System Applied on Biomimetic Organoid Formation,” 2021 Aug., Taoyuan (CGMH).
9.Invited speech, “The Self-designed Bioreactor System Applied on Bone Tissue Engineering,” 2020 Nov., Taipei (TSGH).
10.Invited speech, “The Self-designed Bioreactor System Applied on Bone Tissue Engineering,” 2020 Oct., Hsinchu (NTHU).
11.Invited speech, “The Self-designed Bioreactor System for Bone Regenerative Medicine,” 2020 Oct., Taipei (TMU).
12.Lecturer, “EnSpire: Multilabel Plate Reader,” 2020 Educational training courses of IBEN Service, 2020 Jul., Miaoli (NHRI).
13.Lecturer, “EnSpire: Multilabel Plate Reader,” 2019 Educational training courses of IBEN Service, 2019 Jun., Miaoli (NHRI).
14.Invited speech, “An Overview of the Self-designed Bioreactor System for Tissue Engineering,” 2018 Nov., Taipei (NTNU).
15.Lecturer, “EnSpire: Multilabel Plate Reader,” 2018 Educational training courses of IBEN Service, 2018 Aug., Miaoli (NHRI).
16.Lecturer, “EnSpire: Multilabel Plate Reader,” 2017 Educational training courses of IBEN Service, 2017 Jul., Miaoli (NHRI).
Awards
1.New Faculty Outstanding Award, NCU, Taiwan, 2020.
2.Excellent Poster Paper Award, “Forming One-step Bone-like Tissues in the Self-designed Bioreactor System for Bone Tissue Engineering,” 2020 NHRI Research Day, Taiwan, 2020.
3.13th Tien-Te Lee Distinguished Thesis Awards, “3D Porous Calcium-alginate Scaffolds Cell Culture System Improved Human Osteoblast Cell Clusters for Cell Therapy,” Taiwan, 2017.
4.Poster Paper Award, “Using Preformed Ca-Alginate Scaffolds to Form Human Bone-like Tissues in Continuous Bioreactor System,” 2016 63rd Taiwan Institute of Chemical Engineers Annual Conference, Taiwan, 2016.
5.The Honorable Mention of Young Investigator Award, “Forming Bone-like Tissues for Somatic Cell Therapy via 3D Cell Culture Technique,” 7th World Congress on Preventive & Regenerative Medicine (WCPRM), Taiwan, 2014.
6.Poster Paper Award, “The Preparation of Chondrogenic Construct by the Combination of MSCs and Tri-copolymer with Kartogenin Induction in Functional Closed Perfusion Bioreactor,” Cross-Strait Symposium on Biomaterials and Drug Delivery Systems, Taiwan, 2014.
7.Poster Paper Award, “Purification of CdSe/ZnS Quantum Dots with Single-functional Group,” International Symposium on Biomedical Engineering, Taiwan, 2006.
8.Poster Paper Award, “Study of Monolayer Thermodynamics and Stability of Liposome,” Conference on Engineering Technology and Applications to Chinese and Western Medicine, Taiwan, 2005.
Professional Certifications
1.BioAsia
2.ISO/IEC 17025 Laboratory Management System training course, SGS, 2015/11/21 (Certificate)
3.ISO 17025 Laboratory Management System training course, ITRI, 2015/03/18-2015/03/20 (Certificate)
4.ISO 17025 Team Leader training course, ITRI, 2015/02/12-2015/02/13
Technology Transfer
1.Gwoxi Stem Cell Applied Technology Co., Ltd., “Multi-functional Bioreactor System,” 2016, NT$ 10,000,000.
Projects
1.PI,“To Establish an In-vitro Biomimetic Inner Ear Organoid Formation Platform,” National Central University/Tri-Service General Hospital, 2022, NT$ 250,000.
2.Co-PI,“To Establish an In-vitro Biomimetic Inner Ear Organoid Formation Platform,” Tri-Service General Hospital/National Central University, 2022, NT$ 690,000.
3.Co-PI, “To Develop Personalized Endometrium-like Functional Tissue for Precision Medicine,” Taichung Veterans General Hospital, 2022, NT$ 175,000.
4.PI,“Generating Biomimetic Organotypic 3D Skin Model for Personalized Skin Regeneration on Burn Injury,” National Central University/Landseed International Hospital, 2021-2022, NT$ 161,489.
5.PI,“精準醫療之仿生動態培養系統,” Ministry of Economic Affairs, 2021, NT$ 150,000.
6.Team Member (Technical Consultant), “Multifunctional Biomedical Hydrogel,” Ministry of Economic Affairs, 2021, NT$ 2,850,000.
7.PI,“To Develop Custom Biomimetic Products as Personalized Bone Grafts for Precision Medicine,” Ministry of Science and Technology, 2021-2022, NT$ 900,000.
8.PI,“Biocompatibility/Degradability/Expansion Rate and Commission Test of Bioink,” HORIEN BIOCHEMICAL TECHNOLOGY CO., LTD., 2021, NT$ 97,750.
9.PI,“Using the Self-designed Bioreactor System to Perform Large Amounts of Growth Factors and Exosomes for Skin Care and Regeneration,” Ministry of Science and Technology, 2020-2021, NT$ 400,000.
10.Researcher,“Stimulation of Exosomes from Stem Cells by Engineered Calcium Phosphate Nanoparticles for Their Use as Drug Nano-Carriers,” Ministry of Science and Technology, 2021-2022, NT$ 330,000.
11.Researcher,“Development of Sonodynamic Particles Combining with Low-power Ultrasound for Lipolysis Applications,” Ministry of Health and Welfare, 2020-2021, NT$ 3,330,000.
12.Sub-PI,“Apply Newly Developed Multilayer Capsules on Dentin Pore Filled,” Ministry of Health and Welfare, 2018-2019, NT$ 729,500.
13.Co-PI,“Evaluation of Biological Effectiveness of the 3D-printable Absorbable Bio-ceramics,” Metal Industries Research & Development Centre, 2017, NT$ 500,000.
14.Sub-PI,“The Effect of Antioxidant Supplemented Hyaluronan in Osteoarthritis Cells,” Show Chwan Memorial Hospital, 2016-2018, NT$ 900,000.
15.Sub-PI,“Stem Cell Loaded Drug Eluting Copolymers Scaffold in Cartilage Tissue Engineering Research,” Show Chwan Memorial Hospital, 2016-2018, NT$ 900,000.
16.Co-PI,“A Novel Internal Fixation Porous Bone Screw System,” China Medical University Hospital, 2016, NT$ 194,000.
17.Co-PI,“High Throughput Generation of Alginate-Gelatin/KGN Capsules for WJMSC Encapsulation and Chondrocyte Differentiation,” China Medical University Hospital, 2015, NT$ 388,000.
Publication
i.Journal Papers
1.Deniz Atila, Ching-Yun Chen, Chun-Pin Lin, Yuan-Ling Lee, Vasif Hasirci, Ayşen Tezcaner*, Feng-HueiLin*. “In vitro evaluation of injectable Tideglusib-loaded Hyaluronic Acid Hydrogels Incorporated with Rg1-loaded Chitosan Microspheres for Vital Pulp Regeneration”, Carbohydrate Polymers; 2022 Feb, 278(15): 118976. [SCI, IF = 9.381, 2/77 (CHEMISTRY, APPLIED, 2.6 %), Q1, Time cited: 1]
2.Che-Yung Kuan, Yu-Ying Lin, I-Hsuan Yang, Ching-Yun Chen, Chih-Ying Chi, Chi-Han Li, Zhi-Yu Chen, Li-Ze Lin, Chun-Chen Yang, Feng-Huei Lin*. “The Synthesis of Europium-doped Calcium Carbonate by an Eco-method as Free Radical Generator under Low-intensity Ultrasonic Irradiation for Body Sculpture”, Frontiers in Bioengineering and Biotechnology; 2021 Nov, 19(9): 765630. [SCI, IF = 5.890, 12/72 (Multidisciplinary Sciences, 20.7 %), Q1]
3.Cherng-Jyh Ke, Kuo-Hui Chiu, Ching-Yun Chen, Chiung-Hua Huang*, Chun-Hsu Yao*. “Alginate-gelatin Based Core-shell Capsule Enhances the Osteogenic Potential of Human Osteoblast-like MG-63 Cells”, Materials & Design; 2021 Nov, 210: 110109. [SCI, IF = 7.991, 17/80 (Materials Science, Multidisciplinary, 17.42 %), Q1, Time cited: 1]
4.Wei-Yao Chen, Cherng-Jyh Ke, Ching-Yun Chen, Yu-Ting Chen, Feng-Huei Lin*. “The Synthesis and Evaluation of RGD-Conjugated Chitosan Gel as Daily Supplement for Body Weight Control”, Materials; 2021 Aug, 14(16):4467. [SCI, IF = 3.623, 17/80 (Metallurgy & Metallurgical Engineering, 21.25 %), Q1, Time cited: 1]
5.Chao-Ling Yao, Poyin Huang, Tsai-Chi Liu, Yung-Kai Lin, Ching-Yun Chen, Yi-Ting Lai, Tzu-Yun Chin, and Yi Chiung Hsu*. “CCL2 Associated with CD38 Expression During Ex Vivo Expansion in Human Cord Blood-derived Hematopoietic Stem Cells”, Aging-US; 2021 Aug, 13(15):19878-19893. [SCI, IF = 5.682, 10/53 (Geriatrics & Gerontology, 18.9 %), Q1]
6.Chih-Ying Chi, Ching-Yun Chen, Jian-Yuan Huang, Che-Yung Kuan, Yu-Ying Lin, Chi-Han Li, Chun-Chen Yang, Feng-Huei Lin*. “Preparation and In-vitro Evaluation of Fe2O3-doped DP-bioglass in Combination with 3D-printing and Selective Laser Sintering Process (3DP-SLS) for Alveolar Bone Augmentation”, Ceramics International; 2021 Jan, 47(9): 12725-12734. [SCI, IF = 4.527, 3/29 (MATERIALS SCINCE, CERAMICS, 10.3 %), Q1, Time cited: 3]
7.Ching-Yun Chen†, Chunching Li†, Cherng-Jyh Ke, Jui-Sheng Sun*, Feng-Huei Lin*. “Kartogenin Enhances Chondrogenic Differentiation of MSCs in 3D Tri-Copolymer Scaffolds and the Self-Designed Bioreactor System”, Biomolecules; 2021 Jan, 11(1): 115. [SCI, IF = 4.879, 96/297 (BIOCHEMISTRY & MOLECULAR BIOLOGY, 32.3 %), Q2, Time cited: 5]
8.Chun-Chen Yang, Chong-Xuan Wang, Che-Yung Kuan, Chih-Ying Chi, Ching-Yun Chen, Yu-Ying Lin, Gin-Shin Chen, Chun-Han Hou*, Feng-Huei Lin*. “Using C-doped TiO2 Nanoparticles as a Novel Sonosensitizer for Cancer Treatment”, Antioxidants; 2020 Sep, 9(9): 880. [SCI, IF = 6.312, 11/144 (FOOD SCIENCE & TECHNOLOGY, 7.6 %), Q1, Time cited: 17]
9.Jung-Chih Chen, Chao-Ming Su, Gin-Shin Chen, Chin-Chun Lai, Ching-Yun Chen, Kurt Ming-Chao Lin, Feng-Huei Lin*, Guo-Chung Dong*. “Enhancement of Neurite Outgrowth by Warming Biomaterial Ultrasound Treatment”, International Journal of Molecular Sciences; 2020 Mar, 21(6): 2236. [SCI, IF = 5.923, 67/297 (BIOCHEMISTRY & MOLECULAR BIOLOGY, 22.6 %), Q1, Time cited: 2]
10.Che-Yung Kuan, Yu-Ying Lin, Ching-Yun Chen, Chun-Chen Yang, Chih-Ying Chi, Chi-Han Li, Guo-Chung Dong*, Feng-Huei Lin*. “The preparation of oxidized methylcellulose crosslinked by adipic acid dihydrazide loaded with vitamin C for traumatic brain injury”, Journal of Materials Chemistry B; 2019 Jul, 7: 4499-4508. [SCI, IF = 6.331, 12/40 (MATERIALS SCIENCE, BIOMATERIALS, 30 %), Q2, Time cited: 7]
11.Ching-Yun Chen‡, Kuo-Yun Tseng‡, Zhe-Hong Wong, Ya-Ping Chen, Ting-Yu Chen, Hsuan-Ying Chen, Zih-Ying Chen, Feng-Huei Lin, Hung-Ming Wu, Shankung Lin*. “Cooperative Impact of Thiazolidinedione and Fatty Acid Synthase on Human Osteogenesis”, Aging-US; 2019 Apr, 11(8): 2327–2342. [SCI, IF = 5.682, 10/53 (Geriatrics & Gerontology, 18.9 %), Q1, Time cited: 1]
12.Ching-Yun Chen, Kuo-Yun Tseng, Yen-Liang Lai, Yo-Shen Chen, Feng-Huei Lin*, Shankung Lin*. “Overexpression of Insulin-Like Growth Factor 1 Enhanced the Osteogenic Capability of Aging Bone Marrow Mesenchymal Stem Cells”, Theranostics; 2017 May, 7(6): 1598–1611. [SCI, IF = 11.556, 9/140 (MEDICINE, RESEARCH & EXPERIMENTAL, 6.4 %), Q1, Time cited: 25]
13.Ching-Yun Chen‡, Tsai-Shin Chiang‡, Ling-Ling Chiou, Hsuan-Shu Lee*, Feng-Huei Lin*. “3D Cell Clusters Combined with a Bioreactor System to Enhance the Drug Metabolism Activities of C3A Hepatoma Cell Lines”, Journal of Materials Chemistry B; 2016 Sep, 4: 7000-7008. [SCI, IF = 6.331, 12/40 (MATERIALS SCIENCE, BIOMATERIALS, 30 %), Q2, Time cited: 5]
14.Wei-Ting Kuo, Jian-Yuan Huang, Min-Hua Chen, Ching-Yun Chen, Yan-Jye Shyong, Ko-Chung Yen, Yu-Jun Sun, Cherng-Jyh Ke, Yung-Hsin Cheng, Feng-Huei Lin*. “Development of Gelatin Nanoparticles Conjugated with Phytohemagglutinin Erythroagglutinating Loaded with Gemcitabine for Inducing Apoptosis in Non-small Cell Lung Cancer Cells”, Journal of Materials Chemistry B; 2016 Mar, 4: 2444-2454. [SCI, IF = 6.331, 12/40 (MATERIALS SCIENCE, BIOMATERIALS, 30 %), Q2, Time cited: 14]
15.Ko-Chung Yen, Ching-Yun Chen, Jian-Yuan Huang, Wei-Ting Kuo, Feng-Huei Lin*. “Fabrication of Keratin/Fibroin Membranes by Electrospinning for Vascular Tissue Engineering”, Journal of Materials Chemistry B; 2015 Dec, 4: 237-244. [SCI, SCI, IF = 6.331, 12/40 (MATERIALS SCIENCE, BIOMATERIALS, 30 %), Q2, Time cited: 31]
16.Yu-Ping Chen, Ching-Yun Chen, Cherng-Jyh Ke, Yuan-Hung Chao and Jui-Sheng Sun*. “A Traumatic Brain Injury Result in Accelerated Fracture Healing: A Rat Model”, Journal of Clinical & Experimental Orthopaedics; 2015 Dec, 1: 1-6. [Time cited: 3]
17.Shiow-Yunn Sheu, Yi-Wen Hong, Jui-Sheng Sun*, Man-Hai Liu, Ching-Yun Chen, Cherng-Jyh Ke. “Radix Scrophulariae Extracts (Harpagoside) Suppresses Hypoxia-induced Microglial Activation and Neurotoxicity.” BMC complementary and alternative medicine; 2015 Sep, 15: 324. [SCI, IF = 2.833, 6/28 (INTERGRATIVE & COMPLEMENTARY MEDICINE, 19.6 %), Q1, Time cited: 12]
18.Ching-Yun Chen, Cherng-Jyh Ke, Ko-Chung Yen, Hui-Chen Hsieh, Jui-Sheng Sun*, Feng-Huei Lin*. “3D Porous Calcium-Alginate Scaffolds Cell Culture System Improved Human Osteoblast Cell Clusters for Cell Therapy”, Theranostics; 2015 May, 5(6): 643-655. [SCI, IF = 11.556, 9/140 (MEDICINE, RESEARCH & EXPERIMENTAL, 6.4 %), Q1, Time cited: 52]
19.Hui-Chen Hsieh, Chung-Ming Chen, Wen-Yuan Hsieh, Ching-Yun Chen, Chia-Ching Liu, Feng-Huei Lin*. “ROS-induced Toxicity: Exposure of 3T3, RAW264.7, and MCF7 Cells to Superparamagnetic Iron Oxide Nanoparticles Results in Cell Death by Mitochondria-dependent Apoptosis”, Journal of Nanoparticle Research; 2015 Feb, 17:71. [SCI, IF = 2.132, 97/177 (CHEMISTRY,MULTIDISPLINARY, 64.5 %), Q3, Time cited: 17]
20.Shiow-Yunn Sheu, Shin-Rong Ho, Jui-Sheng Sun*, Ching-Yun Chen, Cherng-Jyh Ke. “Arthropod Steroid Hormone (20-Hydroxyecdysone) Suppresses IL-1β-induced Catabolic Gene Expression in Cartilage.” BMC complementary and alternative medicine; 2015 Jan, 15.1: 1. [SCI, IF = 2.833, 6/28 (INTERGRATIVE & COMPLEMENTARY MEDICINE, 19.6 %), Q1, Time cited: 10]
21.Ruei-Cheng Yang, Ming-Hong Chen, Pei-Yu Chen, Ching-Yun Chen, Shih-Feng Tsai, Cheng-Kung Cheng*, Jui-Sheng Sun*. “A Mutation of the Col2a1 Gene (G1170S) Alters the Transgenic Murine Phenotype and Cartilage Matrix Momeostasis.” Journal of the Formosan Medical Association; 2013 Sep, 113.11: 803-812. [SCI, IF = 3.008, 42/165 (MEDICINE, GENERAL & INTERNAL, 25.1%), Q2, Time cited: 4]
22.Jimmy Kuan-Jung Li, Cherng-Jyh Ke, Cheng-An J. Lin, Zhi-Hua Cai, Ching-Yun Chen, Walter H. Chang*. “Facile Method for Gold Nanocluster Synthesis and Fluorescence Control Using Toluene and Ultrasound”, Journal of Medical and Biological Engineering; 2013 Jan, 33.1: 23-28. [SCI, IF = 1.173, 73/87 (ENGINEERING BIOMEDICAL, 83.3 %), Q4, Time cited: 5]
ii.Conference Papers
1.Ching-Yun Chen and Feng-Huei Lin*, “Forming Chondral-like Tissues in 3D Tri-copolymer Scaffolds and Cultured in the Self-designed Bioreactor,” EORS 2020, Turkey.
2.Ching-Yun Chen and Feng-Huei Lin*, “Forming One-step Bone-like Tissues in the Self-designed Bioreactor System for Bone Tissue Engineering,” 2020 NHRI Research Day, Taiwan. (Excellent Poster Award)
3.Ching-Yun Chen, Kuo-Hui Chiu, Chun-Hsu Yao, and Cherng-Jyh Ke*, “High Throughput Generation of Cell Capsules for Microenvironment Culture system,” TERMIS-ABMC7 2019, Australia.
4.Ching-Yun Chen, and Feng-Huei Lin*, “Enhancing Aging Bone Marrow Mesenchymal Stem Cells toward Osteogenesis via IGF-1 Overexpression for Bone Regeneration,” EWAB-2019, Indonesia.
5.Ching-Yun Chen, Cherng-Jyh Ke‚ Jui-Sheng Sun*, and Feng-Huei Lin*, “Using Continuous Bioreactor System to Cultivate Human Bone-like Tissues for Bone Tissue Engineering,” YUCOMAT 2018, Montenegro.
6.Ching-Yun Chen, Cherng-Jyh Ke, Feng-Huei Lin*, Jui-Sheng Sun*. "Forming Human Bone-like Tissues in Continuous Bioreactor System for Bone Tissue Engineering," 5th Warsaw International Healthcare Exhibition, 2017, Poland.
7.Jia-Wei Lin, Ching-Yun Chen, Li-Ze Lin, Chi-Shinug His, Feng-Huei Lin*."Combining Porous Calcium-Alginate Scaffolds and Continuous Bioreactor System to Form Human Osteoblast Cell Clusters for Cell Therapy,” 2017 Annual Symposium on Biomedical Engineering and Technology, Taiwan.
8.Shiang-Ting Weng‚ Ching-Yun Chen, Jui-Sheng Sun, Hsu-Wei Fang* ‚ and Feng-Huei Lin*, “Using Preformed Ca-Alginate Scaffolds to Form Human Bone-like Tissues in Continuous Bioreactor System,” 2016 63rd Taiwan Institute of Chemical Engineers Annual Conference, Taiwan. (Poster Paper Award)
9.Ching-Yun Chen, Cherng-Jyh Ke‚ and Feng-Huei Lin*, “Effects of Hyaluronic Acid and Statins against LPS-induced Inflammation and Apoptosis in Porcine Articular Chondrocytes,” 2015 Chinese Biomaterials Congress, China.
10.Feng-Huei Lin* and Ching-Yun Chen, “Application of Gelatin/Hyaluronic Acid/Chondroitin-6-Sulfate Tri-copolymer on MSCs Based Cartilage Tissue Engineering,” 2015 Chinese Biomaterials Congress, China.
11.Ching-Yun Chen, Cherng-Jyh Ke, Feng-Huei Lin*, Jui-Sheng Sun*, “Human Osteoblast Cell Clusters Formation in Self-made Bioreactor System for Bone Tissue Engineering,” 21st International Biomedical Science and Technology Symposium (BIOMED 2015)/East West Asia Biomaterials Symposium (EWAB 2015), Turkey.
12.Ching-Yun Chen, Yueh-Sheng Chen, Ning-Yi Tu, Jui-Sheng Sun* and Cherng-Jyh Ke*, “The Thermosensitive Hydrogel Encapsulated with Antibiotic to Prevent the Multidrug Resistant Osteomyelitis in Rat,” 2015 International Biotechnology Chemical Engineering and Life Science Conference, Taiwan.
13.Ching-Yun Chen, Feng-Huei Lin*, Jui-Sheng Sun*, “Porous Calcium-Alginate Scaffolds with Self-designed Bioreactor System Forming Human Osteoblast Cell Clusters for Cell Therapy,” The 5th Asian Biomaterials Congress (2015 ABMC5), Taiwan.
14.Ching-Yun Chen, Cherng-Jyh Ke, Feng-Huei Lin*, Jui-Sheng Sun*, “Forming Bone-like Tissues for Somatic Cell Therapy via 3D Cell Culture Technique,” 7th World Congress on Preventive & Regenerative Medicine (WCPRM 2014), Taiwan. (YIA Award)
15.Ching-Yun Chen, Cherng-Jyh Ke, Jui-Sheng Sun*, Feng-Huei Lin*, “Forming Bone-like Tissues in the Self-made Bioreactor System for Bone Tissue Engineering,” 2014 European Orthopaedic Research Society, France.
16.Cherng-Jyh Ke, Ching-Yun Chen, and Jui-Sheng Sun *, “Hydrogel Encapsulating Antibiotic in Osteomyelitis Prevention in Rats,” 2014 European Orthopaedic Research Society, France.
17.Ching-Yun Chen, Cherng-Jyh Ke, Feng-Huei Lin* ‚ and Jui-Sheng Sun*, “3D Cell Culture in Porous Calcium-Alginate Scaffolds Forming Human Osteoblast Cell Clusters for Cell Therapy,” 2014 Cross-Strait Symposium on Biomaterials and Drug Delivery Systems, Taiwan.
18.Chunching Li, Ching-Yun Chen, Feng-Huei Lin* ‚ and Jui-Sheng Sun*, “The Preparation of Chondrogenic Construct by the Combination of MSCs and Tri-copolymer with Kartogenin Induction in Functional Closed Perfusion Bioreactor,” 2014 Cross-Strait Symposium on Biomaterials and Drug Delivery Systems, Taiwan. (Poster Paper Award)
19.Ching-Yun Chen, Pei-Shan Li, Meng-Yow Hsieh, Hsin-Hsin Shen, Feng-Huei Lin*, Jui-Sheng Sun*, “Improving bone reconstruction in the rat ulnar nonunion model via controlling human recombinant bone morphogenetic protein-2 release,” 3rd Tissue Engineering International & Regenerative Medicine Society World Congress Meeting (3rd TERMIS, World Congress 2012), Austria.
20.Ching-Yun Chen, Pei-Shan Li, Meng-Yow Hsieh, Hsin-Hsin Shen, Yi-Hung Lin, Feng-Huei Lin*, Jui-Sheng Sun*, “Enhanced bone formation via local and controlled release of bone morphogenetic protein-2 from biodegradable hydrogels (PLGA-PEG-PLGA Triblock Copolymer) on critical-size bone defect,” European Orthopaedic Research Society 19th Annual Meeting (EORS 2011), Austria.
21.Ching-Yun Chen, Pei-Shan Li, Meng-Yow Hsieh,Hsin-Hsin Shen, Feng-Huei Lin*, Jui-Sheng Sun*, “Controlled release by biodegradable hydrogels (PLGA-PEG-PLGA triblock copolymer) enhances the bone formation of bone morphogenetic protein on Critical-Size Bone Defect,” European Chapter of Tissue Engineering International & Regenerative Medicine Society Annual Meeting (TERMIS-EU 2011), Spain.
22.Ching-Yun Chen, Pei-Shan Li, Meng-You Hsieh, Yi-Hung Lin, Hsin-Hsin Shen*, and Jui-Sheng Sun*, “Combination of Type I Collagen/PLGA-PEG-PLGA/BMP-2 on Critical-Size Bone Defect Healing,” 2010 Nineteenth Symposium on Recent Advances in Cellular and Molecular Biology, Taiwan.
23.Cheng-An J. Lin, Chih-Hsun Li, Ralph A. Sperling, Ting-Ya Yang, Ching-Yun Chen, Jimmy Kuan-Jung Li, Walter H. Chang＊, and Wolfgang J. Parak＊, “From Quantum Dot Single-Biotinylation to Generate Limited Nanostructurs by Streptavidin” 2008 SPIE Photonics West, USA.
24.Ching-Yun Chen, Cherng-Jyh Ke, Yi-Ting Kuo, Bo-Wen Li, Ming Tzu Tsai, Cheng-An J. Lin, Jimmy Kuan-Jung Li, and Walter H. Chang*, “New Strategy of Purification of CdSe/ZnS Quantum Dots with Controllable and Specific Functional Groups.” 2007 International Conference on Biomedical Engineering, Taiwan.
25.Cherng-Jyh Ke, Ching-Yun Chen, Ting-Ya Yang, Cheng-An J. Lin, and Walter H. Chang*, “The Fluorescent Gold Nanoclusters Prepared by Facile Method.” 2007 International Conference on Biomedical Engineering, Taiwan.
26.Cherng-Jyh Ke, Ching-Yun Chen, Shuai Wang, Jimmy Kuan-Jung Li, Cheng-An J. Lin, and Walter H. Chang*, “Synthesize Fluorescence Gold Nanoclusters by Using Ultrasound Irritation.” 2007 International Symposium on Biomedical Engineering, Taiwan.
27.Ting-Ya Yang, Cheng-An J. Lin, Hsiu-Ting Lin, Cherng-Jyh Ke, Ching-Yun Chen, and and Walter H. Chang*, "Phase Transfer of Fluorescent Gold Clusters and Its Optical Properties", 2007 International Symposium on Biomedical Engineering, Taiwan.
28.Cheng-An J. Lin, Ching-Yun Chen, Cherng-Jyh Ke, Hsiu-Ting Lin, Jimmy Kuan-Jung Li, Walter H. Chang, Ralph A. Sperling, and Wolfgang J. Parak*, “Characterization of Streptavidin-Assembled Nanoparticles by Gel Electrophoresis.” The Fourth Conference of Aseanian Membrane Society (AMS4), 2007.
29.Ho-Shen Li, Cherng-Jyh Ke, Ching-Yun Chen, Chi-Lian Tung, Pei-Hsun Chien., Cheng-An J. Lin, and Walter H. Chang*, “Tunable Emission of Gold Nanoclusters is Regulated by Doping Metal Method.” 2007 International Symposium on Biomedical Engineering, Taiwan.
30.Ching-Yun Chen, Cherng-Jyh Ke, Yi-Ting Kuo, Bo-Wen Li, Cheng-An J. Lin, Jimmy Kuan-Jung Li, and Walter H. Chang*, “Improvement of CdSe/ZnS Quantum Dots Bioconjugation with Controllable and Specific Functional Groups.” 2007 International Symposium on Biomedical Engineering, Taiwan.
31.Yi-Ting Kuo, Ching-Yun Chen, Cherng-Jyh Ke, Bo-Wen Li, Cheng-An J. Lin, Jimmy Kuan-Jung Li, and Walter H. Chang*, “The Bio-Conjugation Efficiency of the Cross-Linker, EDC, Working on The Surface of CdSe Quantum Dots.” 2007 International Symposium on Biomedical Engineering, Taiwan.
32.Cherng-Jyh Ke, Ho-Shen Li, Ching-Yun Chen, Ting-Ya Yang, Cheng-An J. Lin, Jimmy Kuan-Jung Li, and Walter H. Chang*, “The Optical Interactions of Gold Nano-Particles and Copper Nano-Particles after Synthesizing and Doping.” 11th Nano Engineering and Microsystem Technology Conference, Taiwan.
33.Yi-Ting Kuo, Ching-Yun Chen, Cherng-Jyh Ke, Cheng-An J. Lin, Jimmy Kuan-Jung Li, and Walter H. Chang*, “The Bio-conjugation Efficiency of the Cross-Linker, EDC, Working on The Surface of CdSe Quantum Dots.” 11th Nano Engineering and Microsystem Technology Conference, Taiwan.
34.Ching-Yun Chen, Yi-Ping Li, Cherng-Jyh Ke, Yi-Ting Kuo, Hsiu-Ting Lin, Ting-Ya Yang, Jimmy Kuan-Jung Li, and Walter H. Chang*, “The Best Condition of Conjugating Single-Functional Group on Gold Nano-Particles.” 11th Nano Engineering and Microsystem Technology Conference, Taiwan.
35.Cherng-Jyh Ke, Ching-Yun Chen, Yueh-Sheng Chen*, and Walter H. Chang*, “The Evaluation of the Same Cross-Linking Degree Bodegradable Genipin and Glutaraldehyde Cross-Linked Gelatin Peripheral Nerve Guide Conduit Materials.” 2006 International Symposium on Biomedical Engineering, Taiwan.
36.Ching-Yun Chen, Ting-Ya Yang, Cherng-Jyh Ke, Cheng-An J. Lin, Jimmy Kuan-Jung Li, and Walter H. Chang*, “Purification of CdSe/ZnS Quantum Dots with Single-functional Group,” 2006 International Symposium on Biomedical Engineering, Taiwan. (Poster Paper Award)
37.Cherng-Jyh Ke, Ching-Yun Chen, Ting-Ya Yang, Chi-Tsu Yuen, Cheng-An J. Lin, Jimmy Kuan-Jung Li, and Walter H. Chang*, “ZnSe Quantum Dots Synthesis.” 2006 Nano Materials and Technology Symposium, Taiwan.
38.Ching-Yun Chen, Ting-Ya Yang, Cherng-Jyh Ke, Yi-Ping Li, Cheng-An J. Lin, Jimmy Kuan-Jung Li, and Walter H. Chang*, “Optical Properties of CdSe/ZnS Quantum Dots with Single-Functional Group.” 2006 Nano Materials and Technology Symposium, Taiwan.
39.Ching-Yun Chen, Yu-Chian Chen*, Chieh-Hsi Wu, Yueh-Sheng Chen, “Liposome as a Drug Carrier in Inhibiting Smooth Muscle Cell Proliferation,” 2005 Nano Bioengineering International Symposium, Taiwan.
40.Ching-Yun Chen and Yu-Chian Chen*, “Study of Monolayer Kinetics and Stability of Liposome, ” 2005 Annual Symposium on Biomedical Engineering and Technology, Taiwan.
41.Ching-Yun Chen, Chia-Chi Lin, Yu-Chian Chen*, Chieh-Hsi Wu, “Study of Monolayer Thermodynamics and Stability of Liposome,”2005 Conference on Engineering Technology and Applications to Chinese and Western Medicine, Taiwan. (Poster Paper Award)
42.Yu-Chian Chen*, Ching-Yun Chen, and Chia-Chi Lin, “Study of Artificial Alveolar Surfactant Dynamics,” 2005 Conference on Engineering Technology and Applications to Chinese and Western Medicine, Taiwan.
連絡電話：03-4227151轉27765
E-mail：chingyun523@gmail.com
Education
1.Ph.D.: 2008/09-2017/06, Department of Biomedical Engineering, National Taiwan University (NTU), Taiwan
2. Master: 2006/09-2008/06, Department of Biomedical Engineering, Chung Yuan Christian University (CYCU), Taiwan
3. Bachelor: 2002/09-2006/06, Department of Biological Technology, China Medical University (CMU), Taiwan
Experiences
1.2020/08- , Assistant Professor, Department of Biomedical Sciences & Engineering, National Central University, Taiwan
2.2017/08-2020/07, Postdoc Fellow, Institute of Biomedical Engineering & Nanomedicine, National Health Research Institutes (NHRI), Taiwan
3.2019/08-2020/01, Adjunct Assistant Professor, Graduate Program of Biotechnology and Pharmaceutical Industries, National Taiwan Normal University, Taiwan
4.2015/09-2017/07, Research Assistant, Institute of Biomedical Engineering & Nanomedicine, National Health Research Institutes (NHRI), Taiwan
5.2008/09-2015/08, Adjunct Research Assistant, Department of Orthopedics, National Taiwan University Hospital (NTUH), Taiwan
6.2006/09-2008/06, Teaching Assistant, Department of Biomedical Engineering, Chung Yuan Christian University (CYCU), Taiwan
Major
1.Regenerative Medicine
2.Tissue Engineering
3.Stem Cells
4.Biomaterials
Professional Activity
i.International Academic Connections
1.Invited speech, “Forming Chondral-like Tissues in 3D Tri-copolymer Scaffolds and Cultured in the Self-designed Bioreactor,” EORS-2020, 2020 Sep., Turkey (On-line Conference).
2.Invited speech, “Enhancing Aging Bone Morrow MSCs Toward Osteogenesis via IGF-1 Overexpression for Bone Regeneration,” EWAB-2019, 2019 Sep., Indonesia.
3.Invited speech, “Using Continuous Bioreactor System to Cultivate Human Bone-like Tissues for Bone Tissue Engineering,” YUCOMAT 2018 Sep., Montenegro.
4.Invited speech, "Forming Human Bone-like Tissues in Continuous Bioreactor System for Bone Tissue Engineering," 5th Warsaw International Healthcare Exhibition, 2017 Oct., Poland.
Domestic Academic Connections
1.Invited speech, “Applications of In-vitro Three-dimensional Dynamic Bioreactor System in Cell Therapy,” 2022 May, Tainan (NCKU).
2.Invited speech, “Applications of In-vitro Three-dimensional Dynamic Culture System in Regenerative Medicine,” 2022 May, New Taipei (MMC).
3.Invited speech, “In-vitro Biomimetic Tissue Engineering Applied on Regenerative Medicine,” 2022 Apr., Taipei (NTU).
4.Invited speech, “Commercial applications of In-vitro Biomimetic Cell Culture System in Biomedical Field,” 2022 Mar., Taichung (CMU).
5.Invited speech, “In-vitro Biomimetic Tissue Engineering for Regenerative Medicine,” 2022 Feb., Taoyuan (CYCU).
6.Invited speech, “Talking about the Application of the In-vitro Biomimetic Bioreactor System in the Biomedical Industry,” 2021 Nov., Taoyuan (NCU).
7.Invited speech, “The Dynamic 3D Bioreactor System Applied on Biomimetic Organoid Formation,” 2021 Oct., Taoyuan (CYCU).
8.Invited speech, “The Self-designed Dynamic 3D Cell Culture System Applied on Biomimetic Organoid Formation,” 2021 Aug., Taoyuan (CGMH).
9.Invited speech, “The Self-designed Bioreactor System Applied on Bone Tissue Engineering,” 2020 Nov., Taipei (TSGH).
10.Invited speech, “The Self-designed Bioreactor System Applied on Bone Tissue Engineering,” 2020 Oct., Hsinchu (NTHU).
11.Invited speech, “The Self-designed Bioreactor System for Bone Regenerative Medicine,” 2020 Oct., Taipei (TMU).
12.Lecturer, “EnSpire: Multilabel Plate Reader,” 2020 Educational training courses of IBEN Service, 2020 Jul., Miaoli (NHRI).
13.Lecturer, “EnSpire: Multilabel Plate Reader,” 2019 Educational training courses of IBEN Service, 2019 Jun., Miaoli (NHRI).
14.Invited speech, “An Overview of the Self-designed Bioreactor System for Tissue Engineering,” 2018 Nov., Taipei (NTNU).
15.Lecturer, “EnSpire: Multilabel Plate Reader,” 2018 Educational training courses of IBEN Service, 2018 Aug., Miaoli (NHRI).
16.Lecturer, “EnSpire: Multilabel Plate Reader,” 2017 Educational training courses of IBEN Service, 2017 Jul., Miaoli (NHRI).
Awards
1.New Faculty Outstanding Award, NCU, Taiwan, 2020.
2.Excellent Poster Paper Award, “Forming One-step Bone-like Tissues in the Self-designed Bioreactor System for Bone Tissue Engineering,” 2020 NHRI Research Day, Taiwan, 2020.
3.13th Tien-Te Lee Distinguished Thesis Awards, “3D Porous Calcium-alginate Scaffolds Cell Culture System Improved Human Osteoblast Cell Clusters for Cell Therapy,” Taiwan, 2017.
4.Poster Paper Award, “Using Preformed Ca-Alginate Scaffolds to Form Human Bone-like Tissues in Continuous Bioreactor System,” 2016 63rd Taiwan Institute of Chemical Engineers Annual Conference, Taiwan, 2016.
5.The Honorable Mention of Young Investigator Award, “Forming Bone-like Tissues for Somatic Cell Therapy via 3D Cell Culture Technique,” 7th World Congress on Preventive & Regenerative Medicine (WCPRM), Taiwan, 2014.
6.Poster Paper Award, “The Preparation of Chondrogenic Construct by the Combination of MSCs and Tri-copolymer with Kartogenin Induction in Functional Closed Perfusion Bioreactor,” Cross-Strait Symposium on Biomaterials and Drug Delivery Systems, Taiwan, 2014.
7.Poster Paper Award, “Purification of CdSe/ZnS Quantum Dots with Single-functional Group,” International Symposium on Biomedical Engineering, Taiwan, 2006.
8.Poster Paper Award, “Study of Monolayer Thermodynamics and Stability of Liposome,” Conference on Engineering Technology and Applications to Chinese and Western Medicine, Taiwan, 2005.
Professional Certifications
1.BioAsia
2.ISO/IEC 17025 Laboratory Management System training course, SGS, 2015/11/21 (Certificate)
3.ISO 17025 Laboratory Management System training course, ITRI, 2015/03/18-2015/03/20 (Certificate)
4.ISO 17025 Team Leader training course, ITRI, 2015/02/12-2015/02/13
Technology Transfer
1.Gwoxi Stem Cell Applied Technology Co., Ltd., “Multi-functional Bioreactor System,” 2016, NT$ 10,000,000.
Projects
1.PI,“To Establish an In-vitro Biomimetic Inner Ear Organoid Formation Platform,” National Central University/Tri-Service General Hospital, 2022, NT$ 250,000.
2.Co-PI,“To Establish an In-vitro Biomimetic Inner Ear Organoid Formation Platform,” Tri-Service General Hospital/National Central University, 2022, NT$ 690,000.
3.Co-PI, “To Develop Personalized Endometrium-like Functional Tissue for Precision Medicine,” Taichung Veterans General Hospital, 2022, NT$ 175,000.
4.PI,“Generating Biomimetic Organotypic 3D Skin Model for Personalized Skin Regeneration on Burn Injury,” National Central University/Landseed International Hospital, 2021-2022, NT$ 161,489.
5.PI,“精準醫療之仿生動態培養系統,” Ministry of Economic Affairs, 2021, NT$ 150,000.
6.Team Member (Technical Consultant), “Multifunctional Biomedical Hydrogel,” Ministry of Economic Affairs, 2021, NT$ 2,850,000.
7.PI,“To Develop Custom Biomimetic Products as Personalized Bone Grafts for Precision Medicine,” Ministry of Science and Technology, 2021-2022, NT$ 900,000.
8.PI,“Biocompatibility/Degradability/Expansion Rate and Commission Test of Bioink,” HORIEN BIOCHEMICAL TECHNOLOGY CO., LTD., 2021, NT$ 97,750.
9.PI,“Using the Self-designed Bioreactor System to Perform Large Amounts of Growth Factors and Exosomes for Skin Care and Regeneration,” Ministry of Science and Technology, 2020-2021, NT$ 400,000.
10.Researcher,“Stimulation of Exosomes from Stem Cells by Engineered Calcium Phosphate Nanoparticles for Their Use as Drug Nano-Carriers,” Ministry of Science and Technology, 2021-2022, NT$ 330,000.
11.Researcher,“Development of Sonodynamic Particles Combining with Low-power Ultrasound for Lipolysis Applications,” Ministry of Health and Welfare, 2020-2021, NT$ 3,330,000.
12.Sub-PI,“Apply Newly Developed Multilayer Capsules on Dentin Pore Filled,” Ministry of Health and Welfare, 2018-2019, NT$ 729,500.
13.Co-PI,“Evaluation of Biological Effectiveness of the 3D-printable Absorbable Bio-ceramics,” Metal Industries Research & Development Centre, 2017, NT$ 500,000.
14.Sub-PI,“The Effect of Antioxidant Supplemented Hyaluronan in Osteoarthritis Cells,” Show Chwan Memorial Hospital, 2016-2018, NT$ 900,000.
15.Sub-PI,“Stem Cell Loaded Drug Eluting Copolymers Scaffold in Cartilage Tissue Engineering Research,” Show Chwan Memorial Hospital, 2016-2018, NT$ 900,000.
16.Co-PI,“A Novel Internal Fixation Porous Bone Screw System,” China Medical University Hospital, 2016, NT$ 194,000.
17.Co-PI,“High Throughput Generation of Alginate-Gelatin/KGN Capsules for WJMSC Encapsulation and Chondrocyte Differentiation,” China Medical University Hospital, 2015, NT$ 388,000.
Publication
i.Journal Papers
| Journal Papers in recent 5 years： | |||
| SCI | Top 10 % | Q1 | Average IF |
| 13 | 2 | 8 | 6.235 |
1.Deniz Atila, Ching-Yun Chen, Chun-Pin Lin, Yuan-Ling Lee, Vasif Hasirci, Ayşen Tezcaner*, Feng-HueiLin*. “In vitro evaluation of injectable Tideglusib-loaded Hyaluronic Acid Hydrogels Incorporated with Rg1-loaded Chitosan Microspheres for Vital Pulp Regeneration”, Carbohydrate Polymers; 2022 Feb, 278(15): 118976. [SCI, IF = 9.381, 2/77 (CHEMISTRY, APPLIED, 2.6 %), Q1, Time cited: 1]
2.Che-Yung Kuan, Yu-Ying Lin, I-Hsuan Yang, Ching-Yun Chen, Chih-Ying Chi, Chi-Han Li, Zhi-Yu Chen, Li-Ze Lin, Chun-Chen Yang, Feng-Huei Lin*. “The Synthesis of Europium-doped Calcium Carbonate by an Eco-method as Free Radical Generator under Low-intensity Ultrasonic Irradiation for Body Sculpture”, Frontiers in Bioengineering and Biotechnology; 2021 Nov, 19(9): 765630. [SCI, IF = 5.890, 12/72 (Multidisciplinary Sciences, 20.7 %), Q1]
3.Cherng-Jyh Ke, Kuo-Hui Chiu, Ching-Yun Chen, Chiung-Hua Huang*, Chun-Hsu Yao*. “Alginate-gelatin Based Core-shell Capsule Enhances the Osteogenic Potential of Human Osteoblast-like MG-63 Cells”, Materials & Design; 2021 Nov, 210: 110109. [SCI, IF = 7.991, 17/80 (Materials Science, Multidisciplinary, 17.42 %), Q1, Time cited: 1]
4.Wei-Yao Chen, Cherng-Jyh Ke, Ching-Yun Chen, Yu-Ting Chen, Feng-Huei Lin*. “The Synthesis and Evaluation of RGD-Conjugated Chitosan Gel as Daily Supplement for Body Weight Control”, Materials; 2021 Aug, 14(16):4467. [SCI, IF = 3.623, 17/80 (Metallurgy & Metallurgical Engineering, 21.25 %), Q1, Time cited: 1]
5.Chao-Ling Yao, Poyin Huang, Tsai-Chi Liu, Yung-Kai Lin, Ching-Yun Chen, Yi-Ting Lai, Tzu-Yun Chin, and Yi Chiung Hsu*. “CCL2 Associated with CD38 Expression During Ex Vivo Expansion in Human Cord Blood-derived Hematopoietic Stem Cells”, Aging-US; 2021 Aug, 13(15):19878-19893. [SCI, IF = 5.682, 10/53 (Geriatrics & Gerontology, 18.9 %), Q1]
6.Chih-Ying Chi, Ching-Yun Chen, Jian-Yuan Huang, Che-Yung Kuan, Yu-Ying Lin, Chi-Han Li, Chun-Chen Yang, Feng-Huei Lin*. “Preparation and In-vitro Evaluation of Fe2O3-doped DP-bioglass in Combination with 3D-printing and Selective Laser Sintering Process (3DP-SLS) for Alveolar Bone Augmentation”, Ceramics International; 2021 Jan, 47(9): 12725-12734. [SCI, IF = 4.527, 3/29 (MATERIALS SCINCE, CERAMICS, 10.3 %), Q1, Time cited: 3]
7.Ching-Yun Chen†, Chunching Li†, Cherng-Jyh Ke, Jui-Sheng Sun*, Feng-Huei Lin*. “Kartogenin Enhances Chondrogenic Differentiation of MSCs in 3D Tri-Copolymer Scaffolds and the Self-Designed Bioreactor System”, Biomolecules; 2021 Jan, 11(1): 115. [SCI, IF = 4.879, 96/297 (BIOCHEMISTRY & MOLECULAR BIOLOGY, 32.3 %), Q2, Time cited: 5]
8.Chun-Chen Yang, Chong-Xuan Wang, Che-Yung Kuan, Chih-Ying Chi, Ching-Yun Chen, Yu-Ying Lin, Gin-Shin Chen, Chun-Han Hou*, Feng-Huei Lin*. “Using C-doped TiO2 Nanoparticles as a Novel Sonosensitizer for Cancer Treatment”, Antioxidants; 2020 Sep, 9(9): 880. [SCI, IF = 6.312, 11/144 (FOOD SCIENCE & TECHNOLOGY, 7.6 %), Q1, Time cited: 17]
9.Jung-Chih Chen, Chao-Ming Su, Gin-Shin Chen, Chin-Chun Lai, Ching-Yun Chen, Kurt Ming-Chao Lin, Feng-Huei Lin*, Guo-Chung Dong*. “Enhancement of Neurite Outgrowth by Warming Biomaterial Ultrasound Treatment”, International Journal of Molecular Sciences; 2020 Mar, 21(6): 2236. [SCI, IF = 5.923, 67/297 (BIOCHEMISTRY & MOLECULAR BIOLOGY, 22.6 %), Q1, Time cited: 2]
10.Che-Yung Kuan, Yu-Ying Lin, Ching-Yun Chen, Chun-Chen Yang, Chih-Ying Chi, Chi-Han Li, Guo-Chung Dong*, Feng-Huei Lin*. “The preparation of oxidized methylcellulose crosslinked by adipic acid dihydrazide loaded with vitamin C for traumatic brain injury”, Journal of Materials Chemistry B; 2019 Jul, 7: 4499-4508. [SCI, IF = 6.331, 12/40 (MATERIALS SCIENCE, BIOMATERIALS, 30 %), Q2, Time cited: 7]
11.Ching-Yun Chen‡, Kuo-Yun Tseng‡, Zhe-Hong Wong, Ya-Ping Chen, Ting-Yu Chen, Hsuan-Ying Chen, Zih-Ying Chen, Feng-Huei Lin, Hung-Ming Wu, Shankung Lin*. “Cooperative Impact of Thiazolidinedione and Fatty Acid Synthase on Human Osteogenesis”, Aging-US; 2019 Apr, 11(8): 2327–2342. [SCI, IF = 5.682, 10/53 (Geriatrics & Gerontology, 18.9 %), Q1, Time cited: 1]
12.Ching-Yun Chen, Kuo-Yun Tseng, Yen-Liang Lai, Yo-Shen Chen, Feng-Huei Lin*, Shankung Lin*. “Overexpression of Insulin-Like Growth Factor 1 Enhanced the Osteogenic Capability of Aging Bone Marrow Mesenchymal Stem Cells”, Theranostics; 2017 May, 7(6): 1598–1611. [SCI, IF = 11.556, 9/140 (MEDICINE, RESEARCH & EXPERIMENTAL, 6.4 %), Q1, Time cited: 25]
13.Ching-Yun Chen‡, Tsai-Shin Chiang‡, Ling-Ling Chiou, Hsuan-Shu Lee*, Feng-Huei Lin*. “3D Cell Clusters Combined with a Bioreactor System to Enhance the Drug Metabolism Activities of C3A Hepatoma Cell Lines”, Journal of Materials Chemistry B; 2016 Sep, 4: 7000-7008. [SCI, IF = 6.331, 12/40 (MATERIALS SCIENCE, BIOMATERIALS, 30 %), Q2, Time cited: 5]
14.Wei-Ting Kuo, Jian-Yuan Huang, Min-Hua Chen, Ching-Yun Chen, Yan-Jye Shyong, Ko-Chung Yen, Yu-Jun Sun, Cherng-Jyh Ke, Yung-Hsin Cheng, Feng-Huei Lin*. “Development of Gelatin Nanoparticles Conjugated with Phytohemagglutinin Erythroagglutinating Loaded with Gemcitabine for Inducing Apoptosis in Non-small Cell Lung Cancer Cells”, Journal of Materials Chemistry B; 2016 Mar, 4: 2444-2454. [SCI, IF = 6.331, 12/40 (MATERIALS SCIENCE, BIOMATERIALS, 30 %), Q2, Time cited: 14]
15.Ko-Chung Yen, Ching-Yun Chen, Jian-Yuan Huang, Wei-Ting Kuo, Feng-Huei Lin*. “Fabrication of Keratin/Fibroin Membranes by Electrospinning for Vascular Tissue Engineering”, Journal of Materials Chemistry B; 2015 Dec, 4: 237-244. [SCI, SCI, IF = 6.331, 12/40 (MATERIALS SCIENCE, BIOMATERIALS, 30 %), Q2, Time cited: 31]
16.Yu-Ping Chen, Ching-Yun Chen, Cherng-Jyh Ke, Yuan-Hung Chao and Jui-Sheng Sun*. “A Traumatic Brain Injury Result in Accelerated Fracture Healing: A Rat Model”, Journal of Clinical & Experimental Orthopaedics; 2015 Dec, 1: 1-6. [Time cited: 3]
17.Shiow-Yunn Sheu, Yi-Wen Hong, Jui-Sheng Sun*, Man-Hai Liu, Ching-Yun Chen, Cherng-Jyh Ke. “Radix Scrophulariae Extracts (Harpagoside) Suppresses Hypoxia-induced Microglial Activation and Neurotoxicity.” BMC complementary and alternative medicine; 2015 Sep, 15: 324. [SCI, IF = 2.833, 6/28 (INTERGRATIVE & COMPLEMENTARY MEDICINE, 19.6 %), Q1, Time cited: 12]
18.Ching-Yun Chen, Cherng-Jyh Ke, Ko-Chung Yen, Hui-Chen Hsieh, Jui-Sheng Sun*, Feng-Huei Lin*. “3D Porous Calcium-Alginate Scaffolds Cell Culture System Improved Human Osteoblast Cell Clusters for Cell Therapy”, Theranostics; 2015 May, 5(6): 643-655. [SCI, IF = 11.556, 9/140 (MEDICINE, RESEARCH & EXPERIMENTAL, 6.4 %), Q1, Time cited: 52]
19.Hui-Chen Hsieh, Chung-Ming Chen, Wen-Yuan Hsieh, Ching-Yun Chen, Chia-Ching Liu, Feng-Huei Lin*. “ROS-induced Toxicity: Exposure of 3T3, RAW264.7, and MCF7 Cells to Superparamagnetic Iron Oxide Nanoparticles Results in Cell Death by Mitochondria-dependent Apoptosis”, Journal of Nanoparticle Research; 2015 Feb, 17:71. [SCI, IF = 2.132, 97/177 (CHEMISTRY,MULTIDISPLINARY, 64.5 %), Q3, Time cited: 17]
20.Shiow-Yunn Sheu, Shin-Rong Ho, Jui-Sheng Sun*, Ching-Yun Chen, Cherng-Jyh Ke. “Arthropod Steroid Hormone (20-Hydroxyecdysone) Suppresses IL-1β-induced Catabolic Gene Expression in Cartilage.” BMC complementary and alternative medicine; 2015 Jan, 15.1: 1. [SCI, IF = 2.833, 6/28 (INTERGRATIVE & COMPLEMENTARY MEDICINE, 19.6 %), Q1, Time cited: 10]
21.Ruei-Cheng Yang, Ming-Hong Chen, Pei-Yu Chen, Ching-Yun Chen, Shih-Feng Tsai, Cheng-Kung Cheng*, Jui-Sheng Sun*. “A Mutation of the Col2a1 Gene (G1170S) Alters the Transgenic Murine Phenotype and Cartilage Matrix Momeostasis.” Journal of the Formosan Medical Association; 2013 Sep, 113.11: 803-812. [SCI, IF = 3.008, 42/165 (MEDICINE, GENERAL & INTERNAL, 25.1%), Q2, Time cited: 4]
22.Jimmy Kuan-Jung Li, Cherng-Jyh Ke, Cheng-An J. Lin, Zhi-Hua Cai, Ching-Yun Chen, Walter H. Chang*. “Facile Method for Gold Nanocluster Synthesis and Fluorescence Control Using Toluene and Ultrasound”, Journal of Medical and Biological Engineering; 2013 Jan, 33.1: 23-28. [SCI, IF = 1.173, 73/87 (ENGINEERING BIOMEDICAL, 83.3 %), Q4, Time cited: 5]
ii.Conference Papers
1.Ching-Yun Chen and Feng-Huei Lin*, “Forming Chondral-like Tissues in 3D Tri-copolymer Scaffolds and Cultured in the Self-designed Bioreactor,” EORS 2020, Turkey.
2.Ching-Yun Chen and Feng-Huei Lin*, “Forming One-step Bone-like Tissues in the Self-designed Bioreactor System for Bone Tissue Engineering,” 2020 NHRI Research Day, Taiwan. (Excellent Poster Award)
3.Ching-Yun Chen, Kuo-Hui Chiu, Chun-Hsu Yao, and Cherng-Jyh Ke*, “High Throughput Generation of Cell Capsules for Microenvironment Culture system,” TERMIS-ABMC7 2019, Australia.
4.Ching-Yun Chen, and Feng-Huei Lin*, “Enhancing Aging Bone Marrow Mesenchymal Stem Cells toward Osteogenesis via IGF-1 Overexpression for Bone Regeneration,” EWAB-2019, Indonesia.
5.Ching-Yun Chen, Cherng-Jyh Ke‚ Jui-Sheng Sun*, and Feng-Huei Lin*, “Using Continuous Bioreactor System to Cultivate Human Bone-like Tissues for Bone Tissue Engineering,” YUCOMAT 2018, Montenegro.
6.Ching-Yun Chen, Cherng-Jyh Ke, Feng-Huei Lin*, Jui-Sheng Sun*. "Forming Human Bone-like Tissues in Continuous Bioreactor System for Bone Tissue Engineering," 5th Warsaw International Healthcare Exhibition, 2017, Poland.
7.Jia-Wei Lin, Ching-Yun Chen, Li-Ze Lin, Chi-Shinug His, Feng-Huei Lin*."Combining Porous Calcium-Alginate Scaffolds and Continuous Bioreactor System to Form Human Osteoblast Cell Clusters for Cell Therapy,” 2017 Annual Symposium on Biomedical Engineering and Technology, Taiwan.
8.Shiang-Ting Weng‚ Ching-Yun Chen, Jui-Sheng Sun, Hsu-Wei Fang* ‚ and Feng-Huei Lin*, “Using Preformed Ca-Alginate Scaffolds to Form Human Bone-like Tissues in Continuous Bioreactor System,” 2016 63rd Taiwan Institute of Chemical Engineers Annual Conference, Taiwan. (Poster Paper Award)
9.Ching-Yun Chen, Cherng-Jyh Ke‚ and Feng-Huei Lin*, “Effects of Hyaluronic Acid and Statins against LPS-induced Inflammation and Apoptosis in Porcine Articular Chondrocytes,” 2015 Chinese Biomaterials Congress, China.
10.Feng-Huei Lin* and Ching-Yun Chen, “Application of Gelatin/Hyaluronic Acid/Chondroitin-6-Sulfate Tri-copolymer on MSCs Based Cartilage Tissue Engineering,” 2015 Chinese Biomaterials Congress, China.
11.Ching-Yun Chen, Cherng-Jyh Ke, Feng-Huei Lin*, Jui-Sheng Sun*, “Human Osteoblast Cell Clusters Formation in Self-made Bioreactor System for Bone Tissue Engineering,” 21st International Biomedical Science and Technology Symposium (BIOMED 2015)/East West Asia Biomaterials Symposium (EWAB 2015), Turkey.
12.Ching-Yun Chen, Yueh-Sheng Chen, Ning-Yi Tu, Jui-Sheng Sun* and Cherng-Jyh Ke*, “The Thermosensitive Hydrogel Encapsulated with Antibiotic to Prevent the Multidrug Resistant Osteomyelitis in Rat,” 2015 International Biotechnology Chemical Engineering and Life Science Conference, Taiwan.
13.Ching-Yun Chen, Feng-Huei Lin*, Jui-Sheng Sun*, “Porous Calcium-Alginate Scaffolds with Self-designed Bioreactor System Forming Human Osteoblast Cell Clusters for Cell Therapy,” The 5th Asian Biomaterials Congress (2015 ABMC5), Taiwan.
14.Ching-Yun Chen, Cherng-Jyh Ke, Feng-Huei Lin*, Jui-Sheng Sun*, “Forming Bone-like Tissues for Somatic Cell Therapy via 3D Cell Culture Technique,” 7th World Congress on Preventive & Regenerative Medicine (WCPRM 2014), Taiwan. (YIA Award)
15.Ching-Yun Chen, Cherng-Jyh Ke, Jui-Sheng Sun*, Feng-Huei Lin*, “Forming Bone-like Tissues in the Self-made Bioreactor System for Bone Tissue Engineering,” 2014 European Orthopaedic Research Society, France.
16.Cherng-Jyh Ke, Ching-Yun Chen, and Jui-Sheng Sun *, “Hydrogel Encapsulating Antibiotic in Osteomyelitis Prevention in Rats,” 2014 European Orthopaedic Research Society, France.
17.Ching-Yun Chen, Cherng-Jyh Ke, Feng-Huei Lin* ‚ and Jui-Sheng Sun*, “3D Cell Culture in Porous Calcium-Alginate Scaffolds Forming Human Osteoblast Cell Clusters for Cell Therapy,” 2014 Cross-Strait Symposium on Biomaterials and Drug Delivery Systems, Taiwan.
18.Chunching Li, Ching-Yun Chen, Feng-Huei Lin* ‚ and Jui-Sheng Sun*, “The Preparation of Chondrogenic Construct by the Combination of MSCs and Tri-copolymer with Kartogenin Induction in Functional Closed Perfusion Bioreactor,” 2014 Cross-Strait Symposium on Biomaterials and Drug Delivery Systems, Taiwan. (Poster Paper Award)
19.Ching-Yun Chen, Pei-Shan Li, Meng-Yow Hsieh, Hsin-Hsin Shen, Feng-Huei Lin*, Jui-Sheng Sun*, “Improving bone reconstruction in the rat ulnar nonunion model via controlling human recombinant bone morphogenetic protein-2 release,” 3rd Tissue Engineering International & Regenerative Medicine Society World Congress Meeting (3rd TERMIS, World Congress 2012), Austria.
20.Ching-Yun Chen, Pei-Shan Li, Meng-Yow Hsieh, Hsin-Hsin Shen, Yi-Hung Lin, Feng-Huei Lin*, Jui-Sheng Sun*, “Enhanced bone formation via local and controlled release of bone morphogenetic protein-2 from biodegradable hydrogels (PLGA-PEG-PLGA Triblock Copolymer) on critical-size bone defect,” European Orthopaedic Research Society 19th Annual Meeting (EORS 2011), Austria.
21.Ching-Yun Chen, Pei-Shan Li, Meng-Yow Hsieh,Hsin-Hsin Shen, Feng-Huei Lin*, Jui-Sheng Sun*, “Controlled release by biodegradable hydrogels (PLGA-PEG-PLGA triblock copolymer) enhances the bone formation of bone morphogenetic protein on Critical-Size Bone Defect,” European Chapter of Tissue Engineering International & Regenerative Medicine Society Annual Meeting (TERMIS-EU 2011), Spain.
22.Ching-Yun Chen, Pei-Shan Li, Meng-You Hsieh, Yi-Hung Lin, Hsin-Hsin Shen*, and Jui-Sheng Sun*, “Combination of Type I Collagen/PLGA-PEG-PLGA/BMP-2 on Critical-Size Bone Defect Healing,” 2010 Nineteenth Symposium on Recent Advances in Cellular and Molecular Biology, Taiwan.
23.Cheng-An J. Lin, Chih-Hsun Li, Ralph A. Sperling, Ting-Ya Yang, Ching-Yun Chen, Jimmy Kuan-Jung Li, Walter H. Chang＊, and Wolfgang J. Parak＊, “From Quantum Dot Single-Biotinylation to Generate Limited Nanostructurs by Streptavidin” 2008 SPIE Photonics West, USA.
24.Ching-Yun Chen, Cherng-Jyh Ke, Yi-Ting Kuo, Bo-Wen Li, Ming Tzu Tsai, Cheng-An J. Lin, Jimmy Kuan-Jung Li, and Walter H. Chang*, “New Strategy of Purification of CdSe/ZnS Quantum Dots with Controllable and Specific Functional Groups.” 2007 International Conference on Biomedical Engineering, Taiwan.
25.Cherng-Jyh Ke, Ching-Yun Chen, Ting-Ya Yang, Cheng-An J. Lin, and Walter H. Chang*, “The Fluorescent Gold Nanoclusters Prepared by Facile Method.” 2007 International Conference on Biomedical Engineering, Taiwan.
26.Cherng-Jyh Ke, Ching-Yun Chen, Shuai Wang, Jimmy Kuan-Jung Li, Cheng-An J. Lin, and Walter H. Chang*, “Synthesize Fluorescence Gold Nanoclusters by Using Ultrasound Irritation.” 2007 International Symposium on Biomedical Engineering, Taiwan.
27.Ting-Ya Yang, Cheng-An J. Lin, Hsiu-Ting Lin, Cherng-Jyh Ke, Ching-Yun Chen, and and Walter H. Chang*, "Phase Transfer of Fluorescent Gold Clusters and Its Optical Properties", 2007 International Symposium on Biomedical Engineering, Taiwan.
28.Cheng-An J. Lin, Ching-Yun Chen, Cherng-Jyh Ke, Hsiu-Ting Lin, Jimmy Kuan-Jung Li, Walter H. Chang, Ralph A. Sperling, and Wolfgang J. Parak*, “Characterization of Streptavidin-Assembled Nanoparticles by Gel Electrophoresis.” The Fourth Conference of Aseanian Membrane Society (AMS4), 2007.
29.Ho-Shen Li, Cherng-Jyh Ke, Ching-Yun Chen, Chi-Lian Tung, Pei-Hsun Chien., Cheng-An J. Lin, and Walter H. Chang*, “Tunable Emission of Gold Nanoclusters is Regulated by Doping Metal Method.” 2007 International Symposium on Biomedical Engineering, Taiwan.
30.Ching-Yun Chen, Cherng-Jyh Ke, Yi-Ting Kuo, Bo-Wen Li, Cheng-An J. Lin, Jimmy Kuan-Jung Li, and Walter H. Chang*, “Improvement of CdSe/ZnS Quantum Dots Bioconjugation with Controllable and Specific Functional Groups.” 2007 International Symposium on Biomedical Engineering, Taiwan.
31.Yi-Ting Kuo, Ching-Yun Chen, Cherng-Jyh Ke, Bo-Wen Li, Cheng-An J. Lin, Jimmy Kuan-Jung Li, and Walter H. Chang*, “The Bio-Conjugation Efficiency of the Cross-Linker, EDC, Working on The Surface of CdSe Quantum Dots.” 2007 International Symposium on Biomedical Engineering, Taiwan.
32.Cherng-Jyh Ke, Ho-Shen Li, Ching-Yun Chen, Ting-Ya Yang, Cheng-An J. Lin, Jimmy Kuan-Jung Li, and Walter H. Chang*, “The Optical Interactions of Gold Nano-Particles and Copper Nano-Particles after Synthesizing and Doping.” 11th Nano Engineering and Microsystem Technology Conference, Taiwan.
33.Yi-Ting Kuo, Ching-Yun Chen, Cherng-Jyh Ke, Cheng-An J. Lin, Jimmy Kuan-Jung Li, and Walter H. Chang*, “The Bio-conjugation Efficiency of the Cross-Linker, EDC, Working on The Surface of CdSe Quantum Dots.” 11th Nano Engineering and Microsystem Technology Conference, Taiwan.
34.Ching-Yun Chen, Yi-Ping Li, Cherng-Jyh Ke, Yi-Ting Kuo, Hsiu-Ting Lin, Ting-Ya Yang, Jimmy Kuan-Jung Li, and Walter H. Chang*, “The Best Condition of Conjugating Single-Functional Group on Gold Nano-Particles.” 11th Nano Engineering and Microsystem Technology Conference, Taiwan.
35.Cherng-Jyh Ke, Ching-Yun Chen, Yueh-Sheng Chen*, and Walter H. Chang*, “The Evaluation of the Same Cross-Linking Degree Bodegradable Genipin and Glutaraldehyde Cross-Linked Gelatin Peripheral Nerve Guide Conduit Materials.” 2006 International Symposium on Biomedical Engineering, Taiwan.
36.Ching-Yun Chen, Ting-Ya Yang, Cherng-Jyh Ke, Cheng-An J. Lin, Jimmy Kuan-Jung Li, and Walter H. Chang*, “Purification of CdSe/ZnS Quantum Dots with Single-functional Group,” 2006 International Symposium on Biomedical Engineering, Taiwan. (Poster Paper Award)
37.Cherng-Jyh Ke, Ching-Yun Chen, Ting-Ya Yang, Chi-Tsu Yuen, Cheng-An J. Lin, Jimmy Kuan-Jung Li, and Walter H. Chang*, “ZnSe Quantum Dots Synthesis.” 2006 Nano Materials and Technology Symposium, Taiwan.
38.Ching-Yun Chen, Ting-Ya Yang, Cherng-Jyh Ke, Yi-Ping Li, Cheng-An J. Lin, Jimmy Kuan-Jung Li, and Walter H. Chang*, “Optical Properties of CdSe/ZnS Quantum Dots with Single-Functional Group.” 2006 Nano Materials and Technology Symposium, Taiwan.
39.Ching-Yun Chen, Yu-Chian Chen*, Chieh-Hsi Wu, Yueh-Sheng Chen, “Liposome as a Drug Carrier in Inhibiting Smooth Muscle Cell Proliferation,” 2005 Nano Bioengineering International Symposium, Taiwan.
40.Ching-Yun Chen and Yu-Chian Chen*, “Study of Monolayer Kinetics and Stability of Liposome, ” 2005 Annual Symposium on Biomedical Engineering and Technology, Taiwan.
41.Ching-Yun Chen, Chia-Chi Lin, Yu-Chian Chen*, Chieh-Hsi Wu, “Study of Monolayer Thermodynamics and Stability of Liposome,”2005 Conference on Engineering Technology and Applications to Chinese and Western Medicine, Taiwan. (Poster Paper Award)
42.Yu-Chian Chen*, Ching-Yun Chen, and Chia-Chi Lin, “Study of Artificial Alveolar Surfactant Dynamics,” 2005 Conference on Engineering Technology and Applications to Chinese and Western Medicine, Taiwan.
更新日期: 2024-05-24